Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 8/20 | 0.66 |
| ▸ | JAK2 | O60674 | 6/20 | 0.66 |
| ▸ | JAK1 | P23458 | 6/20 | 0.66 |
| ▸ | JAK3 | P52333 | 6/20 | 0.66 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.40 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.40 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.40 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28359071 | 1.00 | TYK2 (0.66) | TYK2JAK2JAK1JAK3PDE4B | |
| SCHEMBL29551923 | 0.93 | TYK2 (0.55) | TYK2JAK2JAK1JAK3PDE4B | |
| SCHEMBL28884120 | 0.93 | TYK2 (0.55) | TYK2JAK2JAK1JAK3PDE4B | |
| SCHEMBL29551995 | 0.87 | JAK2 (0.69) | TYK2JAK2JAK1JAK3EGFR | |
| SCHEMBL28359167 | 0.87 | JAK2 (0.69) | TYK2JAK2JAK1JAK3EGFR | |
| SCHEMBL28359283 | 0.83 | JAK2 (0.64) | TYK2JAK2JAK1JAK3PDE4B | |
| SCHEMBL29552138 | 0.83 | JAK2 (0.64) | TYK2JAK2JAK1JAK3PDE4B | |
| SCHEMBL28359124 | 0.82 | JAK2 (0.66) | TYK2JAK2JAK1JAK3PDE4B | |
| SCHEMBL29551888 | 0.81 | JAK2 (0.59) | TYK2JAK2JAK1JAK3PDE4B | |
| SCHEMBL29552249 | 0.79 | TYK2 (0.58) | TYK2JAK2JAK1JAK3AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110818641-B | Pyridazine-3-formamide compound, preparation method and application thereof in medicine and pharmacology | 北京诺诚健华医药科技有限公司 | 2022-10-14 | — | — | CN | disclosed |
| WO-2022032484-A1 | PYRIDAZINE-3-FORMAMIDE COMPOUND, AND PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF | 北京诺诚健华医药科技有限公司 | 2022-02-17 | — | — | WO | disclosed |