Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 10/20 | 0.55 |
| ▸ | JAK2 | O60674 | 5/20 | 0.55 |
| ▸ | JAK1 | P23458 | 4/20 | 0.55 |
| ▸ | JAK3 | P52333 | 4/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | WEE1 | P30291 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.33 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28359048 | 1.00 | TYK2 (0.55) | TYK2JAK2JAK1JAK3CYP3A4 | |
| SCHEMBL28358941 | 0.91 | TYK2 (0.68) | TYK2JAK2JAK1JAK3CYP3A4 | |
| SCHEMBL28359224 | 0.89 | TYK2 (0.56) | TYK2JAK2JAK1JAK3CYP3A4 | |
| SCHEMBL29922837 | 0.89 | TYK2 (0.56) | TYK2JAK2JAK1JAK3CYP3A4 | |
| SCHEMBL28362691 | 0.85 | TYK2 (0.70) | TYK2JAK2JAK1JAK3WEE1 | |
| SCHEMBL29922584 | 0.84 | SYK (0.35) | TYK2JAK2JAK1JAK3 | |
| SCHEMBL28359081 | 0.84 | SYK (0.35) | TYK2JAK2JAK1JAK3 | |
| SCHEMBL28362942 | 0.84 | TYK2 (0.51) | TYK2JAK2JAK1JAK3ALDH1A1 | |
| SCHEMBL29552194 | 0.84 | TYK2 (0.51) | TYK2JAK2JAK1JAK3ALDH1A1 | |
| SCHEMBL29922746 | 0.81 | TYK2 (0.81) | TYK2JAK2JAK1JAK3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110818641-B | Pyridazine-3-formamide compound, preparation method and application thereof in medicine and pharmacology | 北京诺诚健华医药科技有限公司 | 2022-10-14 | — | — | CN | disclosed |
| WO-2022032484-A1 | PYRIDAZINE-3-FORMAMIDE COMPOUND, AND PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF | 北京诺诚健华医药科技有限公司 | 2022-02-17 | — | — | WO | disclosed |