Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 9/20 | 0.40 |
| ▸ | FAAH | O00519 | 3/20 | 0.40 |
| ▸ | RAF1 | P04049 | 1/20 | 0.37 |
| ▸ | DGAT1 | O75907 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CASP3 | P42574 | 1/20 | 0.35 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.35 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.35 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.35 |
| ▸ | SOAT1 | P35610 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29922760 | 0.89 | SYK (0.41) | SYKEPHX2FAAHMEN1KMT2A | |
| SCHEMBL28359219 | 0.89 | SYK (0.41) | SYKEPHX2FAAHMEN1KMT2A | |
| SCHEMBL29552251 | 0.81 | JAK2 (0.42) | EPHX2FAAHDGAT1SOAT1 | |
| SCHEMBL29551896 | 0.75 | EHMT2 (0.47) | SYKMEN1KMT2ANPC1RAB9A | |
| SCHEMBL29552460 | 0.72 | PARP10 (0.39) | SYKEPHX2FAAHDGAT1MEN1 | |
| SCHEMBL29552492 | 0.71 | SYK (0.46) | SYKMEN1KMT2ANPC1RAB9A | |
| SCHEMBL29552431 | 0.70 | SYK (0.48) | SYKMEN1KMT2ANPC1RAB9A | |
| SCHEMBL29553126 | 0.69 | SYK (0.41) | SYKEPHX2MEN1KMT2ALMNA | |
| SCHEMBL29552398 | 0.68 | JAK2 (0.54) | DGAT1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL19021216 | 0.67 | HCAR3 (0.42) | SYKMEN1KMT2AALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022032484-A1 | PYRIDAZINE-3-FORMAMIDE COMPOUND, AND PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF | 北京诺诚健华医药科技有限公司 | 2022-02-17 | — | — | WO | disclosed |