Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.54 |
| ▸ | JAK1 | P23458 | 1/20 | 0.54 |
| ▸ | TYK2 | P29597 | 1/20 | 0.54 |
| ▸ | JAK3 | P52333 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 6/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.47 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.47 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | PIM1 | P11309 | 1/20 | 0.45 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.45 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28359240 | 0.87 | JAK2 (0.52) | JAK2JAK1TYK2JAK3MAPT | |
| SCHEMBL29922581 | 0.87 | JAK2 (0.52) | JAK2JAK1TYK2JAK3MAPT | |
| SCHEMBL29552999 | 0.85 | TYK2 (0.57) | JAK2JAK1TYK2JAK3MAPT | |
| SCHEMBL29552260 | 0.85 | MAPT (0.52) | MAPTSMN1; SMN2LMNAHTTDGAT1 | |
| SCHEMBL29552183 | 0.80 | TYK2 (0.85) | JAK2JAK1TYK2JAK3MAPT | |
| SCHEMBL29553126 | 0.77 | SYK (0.41) | JAK2JAK1TYK2JAK3MAPT | |
| SCHEMBL29552160 | 0.76 | L3MBTL1 (0.46) | JAK2JAK1TYK2JAK3MAPKAPK2 | |
| SCHEMBL29552492 | 0.75 | SYK (0.46) | MAPTMEN1KMT2ALMNAMAPKAPK2 | |
| SCHEMBL5027838 | 0.74 | MAPK9 (0.58) | JAK2JAK1TYK2JAK3MAPT | |
| SCHEMBL29551843 | 0.74 | SYK (0.41) | JAK2JAK1TYK2JAK3MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022032484-A1 | PYRIDAZINE-3-FORMAMIDE COMPOUND, AND PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF | 北京诺诚健华医药科技有限公司 | 2022-02-17 | — | — | WO | disclosed |