Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | FPR2 | P25090 | 3/20 | 0.47 |
| ▸ | PROKR1 | Q8TCW9 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.46 |
| ▸ | LIPE | Q05469 | 3/20 | 0.43 |
| ▸ | BCHE | P06276 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | MMP13 | P45452 | 2/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | MMP12 | P39900 | 1/20 | 0.43 |
| ▸ | MMP14 | P50281 | 1/20 | 0.43 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2056202 | 0.88 | KCNH2 (0.58) | KCNH2FPR2PROKR1MAPTPTGS1 | |
| SCHEMBL3038315 | 0.87 | CARM1 (0.49) | KCNH2SMN1; SMN2LMNALIPEBCHE | |
| SCHEMBL2955257 | 0.85 | KCNH2 (0.47) | KCNH2FPR2PROKR1MEN1KMT2A | |
| SCHEMBL14053224 | 0.82 | KCNH2 (0.47) | KCNH2FPR2PROKR1MEN1KMT2A | |
| SCHEMBL2553568 | 0.81 | GPR119 (0.56) | KCNH2FPR2PROKR1PTGS1SLC6A2 | |
| SCHEMBL12284379 | 0.81 | GPR119 (0.56) | KCNH2FPR2PROKR1PTGS1SLC6A2 | |
| SCHEMBL15441936 | 0.80 | BCHE (0.47) | MEN1KMT2AMAPTSMN1; SMN2LMNA | |
| SCHEMBL2233889 | 0.80 | BCHE (0.57) | MEN1KMT2AMAPTSMN1; SMN2LMNA | |
| SCHEMBL2357937 | 0.79 | KCNH2 (0.47) | KCNH2FPR2PROKR1PTGS1SLC6A2 | |
| SCHEMBL19809288 | 0.79 | KCNH2 (0.47) | KCNH2FPR2PROKR1PTGS1SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3275862-B1 | METHOD FOR PRODUCING 1-(4-HYDROXYPHENYL)-4-(4-TRIFLUOROMETHOXYPHENOXY)PIPERIDINE OR SALT THEREOF | OTSUKA PHARMA CO LTD (JP) | 2020-08-12 | — | — | EP | disclosed |
| US-10252995-B2 | Method for producing 1-(4-hydroxyphenyl)-4-(4-trifluoromethoxyphenoxy)piperidine or salt thereof | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2019-04-09 | — | — | US | disclosed |
| US-20180065931-A1 | METHOD FOR PRODUCING 1-(4-HYDROXYPHENYL)-4-(4-TRIFLUOROMETHOXYPHENOXY)PIPERIDINE OR SALT THEREOF | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2018-03-08 | — | — | US | disclosed |
| EP-3275862-A1 | METHOD FOR PRODUCING 1-(4-HYDROXYPHENYL)-4-(4-TRIFLUOROMETHOXYPHENOXY)PIPERIDINE OR SALT THEREOF | Otsuka Pharmaceutical Co., Ltd. (JP) | 2018-01-31 | — | — | EP | disclosed |
| EP-1727782-B1 | METHOD OF PRODUCING AMINOPHENOL COMPOUNDS | OTSUKA PHARMA CO LTD (JP) | 2012-08-22 | — | — | EP | disclosed |
| US-7750156-B2 | Method of producing aminophenol compounds | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2010-07-06 | — | — | US | disclosed |
| US-20070219374-A1 | Method of Producing Aminophenol Compounds | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2007-09-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180065931-A1 | METHOD FOR PRODUCING 1-(4-HYDROXYPHENYL)-4-(4-TRIFLUOROMETHOXYPHENOXY)PIPERIDINE OR SALT THEREOF | DHPS, PAH, HPD | KCNH2 174/4885FPR2 3807/4885PROKR1 4301/4885 |
| US-20070219374-A1 | Method of Producing Aminophenol Compounds | PAH, CYP1A1, CYP1B1 | KCNH2 3236/4885FPR2 848/4885PROKR1 3094/4885 |
| US-10252995-B2 | Method for producing 1-(4-hydroxyphenyl)-4-(4-trifluoromethoxyphenoxy)piperidine or salt thereof | DHPS, PAH, HPD | KCNH2 174/4885FPR2 3807/4885PROKR1 4301/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.