Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CD274 | Q9NZQ7 | 12/20 | 1.00 |
| ▸ | PDCD1 | Q15116 | 3/20 | 1.00 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.48 |
| ▸ | DPP4 | P27487 | 1/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL358303 | 1.00 | CD274 (1.00) | CD274PDCD1EPHX1DPP4PTGS1 | |
| SCHEMBL16245269 | 0.87 | PDCD1 (0.76) | CD274PDCD1EPHX1PTGS1KMT2A | |
| SCHEMBL607544 | 0.83 | CD274 (0.71) | CD274PDCD1EPHX1DPP4PTGS1 | |
| SCHEMBL18367730 | 0.82 | CD274 (0.70) | CD274PDCD1EPHX1KMT2AHSD17B10 | |
| SCHEMBL22401073 | 0.82 | PDCD1 (0.70) | CD274PDCD1EPHX1PTGS1 | |
| SCHEMBL30828918 | 0.82 | PDCD1 (0.70) | CD274PDCD1EPHX1PTGS1 | |
| SCHEMBL11074941 | 0.82 | PDCD1 (0.69) | CD274PDCD1EPHX1ALDH1A1 | |
| SCHEMBL30091380 | 0.82 | PDCD1 (0.69) | CD274PDCD1EPHX1ALDH1A1 | |
| SCHEMBL21153739 | 0.82 | CD274 (0.69) | CD274PDCD1EPHX1DPP4PTGS1 | |
| SCHEMBL7107915 | 0.82 | CD274 (0.69) | CD274PDCD1EPHX1DPP4PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114573563-A | Bifunctional molecular compound for inducing PD-L1 protein degradation and preparation and application thereof | 沈阳药科大学 | 2022-06-03 | — | — | CN | claimed |
| CN-119768390-A | Novel bicyclo PD-L1 inhibitor and preparation method and medical application thereof | 西安新通药物研究股份有限公司 | 2025-04-04 | — | — | CN | disclosed |
| CN-119350185-A | Biphenyl hydroxamic derivative and preparation method and application thereof | 聊城大学 | 2025-01-24 | — | — | CN | disclosed |
| WO-2025007113-A2 | MITOCHONDRIAL COMPLEX I INHIBITORS WITH REDUCED PHOSPHODIESTERASE INHIBITION | OHIO STATE INNOVATION FOUNDATION (US) | 2025-01-02 | — | — | WO | disclosed |
| CN-116283896-B | Biphenyl compound with PD-L1 inhibition activity and application thereof | 广东晨康生物科技有限公司 | 2024-10-29 | — | — | CN | disclosed |
| CN-114573563-B | Bifunctional molecular compound for inducing PD-L1 protein degradation and preparation and application thereof | 沈阳药科大学 | 2024-07-02 | — | — | CN | disclosed |
| CN-117986158-A | Substituted biphenyl compound, preparation method and application | 云南大学 | 2024-05-07 | — | — | CN | disclosed |
| EP-4359391-A1 | TRIAZINE DERIVATIVES FOR THE TREATMENT OF TUMOURS AND NEURODEGENERATIVE DISORDERS | UNIVERSITA' DEGLI STUDI DI MILANO (IT) | 2024-05-01 | — | — | EP | disclosed |
| CN-113582971-B | Small molecule immunosuppressant, preparation method and application thereof | 北京康辰药业股份有限公司 | 2023-10-20 | — | — | CN | disclosed |
| EP-4117647-A1 | COMPOUNDS WITH IMMUNOMODULATORY ACTIVITY AND THERAPEUTIC USES THEREOF | Purdue Research Foundation (US) | 2023-01-18 | — | — | EP | disclosed |
| WO-2022269532-A1 | TRIAZINE DERIVATIVES FOR THE TREATMENT OF TUMOURS AND NEURODEGENERATIVE DISORDERS | UNIVERSITA' DEGLI STUDI DI MILANO (IT) | 2022-12-29 | — | — | WO | disclosed |
| CN-113387840-B | PD-1/PD-L1 and HDACs double-target inhibitor, preparation method and application | 中国药科大学 | 2022-11-08 | — | — | CN | disclosed |
| CN-114573563-A | Bifunctional molecular compound for inducing PD-L1 protein degradation and preparation and application thereof | 沈阳药科大学 | 2022-06-03 | — | — | CN | disclosed |
| CN-112724148-B | Imidazopyridazine compound, modified amphiphilic functional molecule and application thereof | 上海药明康德新药开发有限公司 | 2022-04-12 | — | — | CN | disclosed |