Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 9/20 | 0.63 |
| ▸ | INSR | P06213 | 5/20 | 0.63 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.56 |
| ▸ | EGFR | P00533 | 8/20 | 0.53 |
| ▸ | IGF1R | P08069 | 3/20 | 0.53 |
| ▸ | ZAP70 | P43403 | 2/20 | 0.53 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.52 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.52 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.52 |
| ▸ | BTK | Q06187 | 2/20 | 0.51 |
| ▸ | CDC7 | O00311 | 1/20 | 0.51 |
| ▸ | PLK4 | O00444 | 1/20 | 0.51 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.51 |
| ▸ | AURKA | O14965 | 1/20 | 0.51 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.51 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.51 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.51 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.51 |
| ▸ | JAK2 | O60674 | 1/20 | 0.51 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22942878 | 1.00 | ALK (0.63) | ALKINSRLRRK2EGFRIGF1R | |
| SCHEMBL29560293 | 0.91 | ALK (0.58) | ALKINSREGFRIGF1R | |
| SCHEMBL22942149 | 0.86 | INSR (0.69) | ALKINSRLRRK2EGFRIGF1R | |
| SCHEMBL22942228 | 0.86 | EGFR (0.64) | ALKINSRLRRK2EGFRIGF1R | |
| SCHEMBL22943345 | 0.85 | EGFR (0.56) | ALKINSREGFRIGF1RZAP70 | |
| SCHEMBL29560175 | 0.82 | EGFR (0.55) | LRRK2EGFRJAK2 | |
| SCHEMBL22942226 | 0.80 | EGFR (0.56) | ALKINSREGFRIGF1RPLK1 | |
| SCHEMBL22942163 | 0.79 | INSR (0.60) | ALKINSRLRRK2EGFRIGF1R | |
| SCHEMBL22942156 | 0.79 | INSR (0.61) | ALKINSRLRRK2EGFRIGF1R | |
| SCHEMBL25449607 | 0.77 | EGFR (0.55) | ALKINSRLRRK2EGFRMAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114430740-A | EGFR inhibitor, composition and preparation method thereof | 贝达药业股份有限公司 | 2022-05-03 | — | — | CN | claimed |
| CN-114430740-B | EGFR inhibitors, compositions and methods of making the same | 贝达药业股份有限公司 | 2023-12-29 | — | — | CN | disclosed |
| CN-114430740-A | EGFR inhibitor, composition and preparation method thereof | 贝达药业股份有限公司 | 2022-05-03 | — | — | CN | disclosed |