Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 7/20 | 0.58 |
| ▸ | INSR | P06213 | 3/20 | 0.58 |
| ▸ | IGF1R | P08069 | 3/20 | 0.58 |
| ▸ | EGFR | P00533 | 8/20 | 0.56 |
| ▸ | BRD4 | O60885 | 3/20 | 0.56 |
| ▸ | JAK3 | P52333 | 1/20 | 0.54 |
| ▸ | AXL | P30530 | 1/20 | 0.51 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22942149 | 0.93 | INSR (0.69) | ALKINSRIGF1REGFR | |
| SCHEMBL22942878 | 0.91 | ALK (0.63) | ALKINSRIGF1REGFR | |
| SCHEMBL29559900 | 0.91 | ALK (0.63) | ALKINSRIGF1REGFR | |
| SCHEMBL22942141 | 0.86 | EGFR (0.69) | ALKINSRIGF1REGFR | |
| SCHEMBL22943345 | 0.86 | EGFR (0.56) | ALKINSRIGF1REGFR | |
| SCHEMBL22942163 | 0.86 | INSR (0.60) | ALKINSRIGF1REGFR | |
| SCHEMBL22942156 | 0.85 | INSR (0.61) | ALKINSRIGF1REGFR | |
| SCHEMBL24179137 | 0.84 | ALK (0.73) | ALKINSRIGF1REGFR | |
| SCHEMBL24179052 | 0.81 | INSR (0.69) | ALKINSRIGF1REGFR | |
| SCHEMBL22942226 | 0.81 | EGFR (0.56) | ALKINSRIGF1REGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114430740-B | EGFR inhibitors, compositions and methods of making the same | 贝达药业股份有限公司 | 2023-12-29 | — | — | CN | claimed |
| CN-114430740-A | EGFR inhibitor, composition and preparation method thereof | 贝达药业股份有限公司 | 2022-05-03 | — | — | CN | claimed |
| CN-114430740-B | EGFR inhibitors, compositions and methods of making the same | 贝达药业股份有限公司 | 2023-12-29 | — | — | CN | disclosed |
| CN-114430740-A | EGFR inhibitor, composition and preparation method thereof | 贝达药业股份有限公司 | 2022-05-03 | — | — | CN | disclosed |