Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EIF4EBP1 | Q13541 | 11/20 | 0.39 |
| ▸ | MYC | P01106 | 2/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.32 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | CSF1R | P07333 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22866770 | 0.89 | EIF4EBP1 (0.34) | EIF4EBP1EGFRGPR35SORT1KDM4E | |
| SCHEMBL28715107 | 0.79 | GPR35 (0.45) | EIF4EBP1GPR35SORT1KDM4E | |
| SCHEMBL29560054 | 0.79 | KDM4E (0.39) | GPR35KDM4EALDH1A1 | |
| SCHEMBL22866725 | 0.79 | KDM4E (0.39) | GPR35KDM4EALDH1A1 | |
| SCHEMBL22866908 | 0.79 | EIF4EBP1 (0.37) | EIF4EBP1GPR35SORT1KDM4EALDH1A1 | |
| SCHEMBL29559766 | 0.79 | EIF4EBP1 (0.37) | EIF4EBP1GPR35SORT1KDM4EALDH1A1 | |
| SCHEMBL22866911 | 0.78 | CD38 (0.39) | GPR35KDM4EALDH1A1GAA | |
| SCHEMBL22866471 | 0.74 | L3MBTL1 (0.34) | EIF4EBP1GPR35KDM4E | |
| SCHEMBL22866922 | 0.66 | CYP2A6 (0.35) | GPR35 | |
| SCHEMBL22866921 | 0.66 | MAPT (0.33) | GPR35GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114269756-B | 4-Oxo-3, 4-dihydropyrido [3,4-D ] pyrimidine compounds that inhibit EIF4E | 效应疗法股份有限公司 | 2024-05-14 | — | — | CN | disclosed |
| EP-3994139-A1 | EIF4E-INHIBITING 4-OXO-3,4-DIHYDROPYRIDO[3,4-D]PYRIMIDINE COMPOUNDS | Effector Therapeutics Inc. (US) | 2022-05-11 | — | — | EP | disclosed |
| CN-114269756-A | 4-oxo-3, 4-dihydropyrido [3,4-D ] pyrimidine compounds inhibiting EIF4E | 效应疗法股份有限公司 | 2022-04-01 | — | — | CN | disclosed |