Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.44 |
| ▸ | JAK2 | O60674 | 10/20 | 0.43 |
| ▸ | JAK1 | P23458 | 10/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22866759 | 1.00 | GPR119 (0.44) | GPR119JAK2JAK1HDAC1HDAC2 | |
| SCHEMBL31046508 | 0.84 | GPR119 (0.41) | GPR119JAK2JAK1HDAC1HDAC2 | |
| SCHEMBL29335912 | 0.84 | GPR119 (0.41) | GPR119JAK2JAK1HDAC1HDAC2 | |
| SCHEMBL29335913 | 0.84 | GPR119 (0.41) | GPR119JAK2JAK1HDAC1HDAC2 | |
| SCHEMBL31046207 | 0.84 | GPR119 (0.41) | GPR119JAK2JAK1HDAC1HDAC2 | |
| SCHEMBL1995189 | 0.82 | CTSL (0.47) | GPR119JAK2JAK1 | |
| SCHEMBL3051647 | 0.82 | POLB (0.47) | GPR119JAK2JAK1 | |
| SCHEMBL22866761 | 0.82 | GPR119 (0.40) | GPR119JAK2JAK1HDAC1HDAC2 | |
| SCHEMBL31417067 | 0.81 | JAK2 (0.50) | GPR119JAK2JAK1HDAC1HDAC2 | |
| SCHEMBL31349521 | 0.80 | GPR119 (0.43) | GPR119JAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114269756-B | 4-Oxo-3, 4-dihydropyrido [3,4-D ] pyrimidine compounds that inhibit EIF4E | 效应疗法股份有限公司 | 2024-05-14 | — | — | CN | disclosed |
| EP-3994139-A1 | EIF4E-INHIBITING 4-OXO-3,4-DIHYDROPYRIDO[3,4-D]PYRIMIDINE COMPOUNDS | Effector Therapeutics Inc. (US) | 2022-05-11 | — | — | EP | disclosed |
| CN-114269756-A | 4-oxo-3, 4-dihydropyrido [3,4-D ] pyrimidine compounds inhibiting EIF4E | 效应疗法股份有限公司 | 2022-04-01 | — | — | CN | disclosed |