Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | SYK | P43405 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 2/20 | 0.40 |
| ▸ | JAK1 | P23458 | 2/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | ACACB | O00763 | 2/20 | 0.38 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29335912 | 1.00 | GPR119 (0.41) | GPR119HDAC1HDAC2SYKJAK2 | |
| SCHEMBL31046508 | 0.88 | GPR119 (0.41) | GPR119HDAC1HDAC2JAK2JAK1 | |
| SCHEMBL29335913 | 0.88 | GPR119 (0.41) | GPR119HDAC1HDAC2JAK2JAK1 | |
| SCHEMBL9998899 | 0.85 | GPR119 (0.41) | GPR119HDAC1HDAC2SYKROCK2 | |
| SCHEMBL29560741 | 0.84 | GPR119 (0.44) | GPR119HDAC1HDAC2JAK2JAK1 | |
| SCHEMBL22866759 | 0.84 | GPR119 (0.44) | GPR119HDAC1HDAC2JAK2JAK1 | |
| SCHEMBL9998878 | 0.81 | ACACB (0.42) | GPR119SYKROCK2ACACBPKM | |
| SCHEMBL12074307 | 0.81 | GPR119 (0.41) | GPR119HDAC1HDAC2SYKACACB | |
| SCHEMBL15992767 | 0.81 | GPR119 (0.41) | GPR119SYKROCK2ACACBPKM | |
| SCHEMBL30833113 | 0.80 | PIK3CA (0.49) | GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4649077-A1 | SPIRO DERIVATIVES AS M4 ACTIVATORS/MODULATORS AND USES THEREOF | Cerevel Therapeutics, LLC (US) | 2025-11-19 | — | — | EP | disclosed |
| WO-2024151833-A1 | SPIRO DERIVATIVES AS M4 ACTIVATORS/MODULATORS AND USES THEREOF | CEREVEL THERAPEUTICS, LLC (US) | 2024-07-18 | — | — | WO | disclosed |