Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT6 | Q8N6T7 | 3/20 | 0.65 |
| ▸ | LMNA | P02545 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | GPR27 | Q9NS67 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | CCR2 | P41597 | 3/20 | 0.39 |
| ▸ | ACLY | P53396 | 1/20 | 0.38 |
| ▸ | WDR5 | P61964 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29562488 | 0.83 | SIRT6 (0.71) | SIRT6LMNAALDH1A1HTTGAA | |
| SCHEMBL29561267 | 0.80 | SIRT6 (0.72) | SIRT6LMNAALDH1A1THRBGPR27 | |
| SCHEMBL29561258 | 0.79 | SIRT6 (1.00) | SIRT6ALDH1A1GPR27ACLY | |
| SCHEMBL23260622 | 0.79 | SIRT6 (0.70) | SIRT6PKMACLY | |
| SCHEMBL29561557 | 0.79 | SIRT6 (0.73) | SIRT6LMNAALDH1A1GPR27PKM | |
| SCHEMBL23261499 | 0.78 | SIRT6 (0.75) | SIRT6ALDH1A1GAAGPR27PKM | |
| SCHEMBL23261498 | 0.78 | SIRT6 (0.84) | SIRT6GPR27ACLY | |
| SCHEMBL23260610 | 0.78 | SIRT6 (0.84) | SIRT6GPR27ACLY | |
| SCHEMBL23246158 | 0.77 | SIRT6 (0.83) | SIRT6GPR27ACLY | |
| SCHEMBL23260707 | 0.77 | SIRT6 (0.68) | SIRT6LMNAMEN1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109384694-B | SIRT6 small-molecule agonist and application thereof | 上海爱乐维生物科技有限公司 | 2022-04-05 | — | — | CN | claimed |