Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.61 |
| ▸ | PTGES2 | Q9H7Z7 | 4/20 | 0.54 |
| ▸ | PGR | P06401 | 1/20 | 0.54 |
| ▸ | PKM | P14618 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | SLC40A1 | Q9NP59 | 2/20 | 0.49 |
| ▸ | CCR4 | P51679 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | SGK1 | O00141 | 1/20 | 0.47 |
| ▸ | CRHBP | P24387 | 1/20 | 0.46 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.46 |
| ▸ | BRD4 | O60885 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29562337 | 0.86 | MAPT (0.58) | MAPTPTGES2PKMALDH1A1SLC40A1 | |
| SCHEMBL29561514 | 0.85 | MAPT (0.65) | MAPTPGRPKMALDH1A1SLC40A1 | |
| SCHEMBL29561330 | 0.85 | MAPT (0.61) | MAPTALDH1A1 | |
| SCHEMBL29562105 | 0.84 | MAPT (0.61) | MAPTPGRPKMALDH1A1SLC40A1 | |
| SCHEMBL29562498 | 0.84 | ALDH1A1 (0.62) | MAPTPGRPKMALDH1A1LMNA | |
| SCHEMBL29561428 | 0.83 | SLC22A12 (0.57) | MAPTPKMALDH1A1SLC40A1SGK1 | |
| SCHEMBL29562114 | 0.83 | MAPT (0.66) | MAPTPGRPKMALDH1A1LMNA | |
| SCHEMBL29562119 | 0.81 | MAPT (0.64) | MAPTPGRPKMALDH1A1LMNA | |
| SCHEMBL29561322 | 0.81 | MAPT (0.60) | MAPTPKMLMNATP53POLB | |
| SCHEMBL29561463 | 0.81 | MAPT (0.67) | MAPTPGRPKMALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109384694-B | SIRT6 small-molecule agonist and application thereof | 上海爱乐维生物科技有限公司 | 2022-04-05 | — | — | CN | disclosed |