Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | TTR | P02766 | 2/20 | 0.33 |
| ▸ | PPOX | P50336 | 1/20 | 0.33 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.33 |
| ▸ | ALB | P02768 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.32 |
| ▸ | WDR5 | P61964 | 2/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | GRM6 | O15303 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22831871 | 1.00 | LMNA (0.35) | LMNAPOLBSMN1; SMN2MAPTKMT2A | |
| SCHEMBL29562112 | 0.91 | HSPB1 (0.34) | LMNAPOLBSMN1; SMN2MAPTKMT2A | |
| SCHEMBL22832025 | 0.91 | HSPB1 (0.34) | LMNAPOLBSMN1; SMN2MAPTKMT2A | |
| SCHEMBL22832028 | 0.89 | LMNA (0.36) | LMNAPOLBSMN1; SMN2MAPTKMT2A | |
| SCHEMBL29561773 | 0.89 | LMNA (0.36) | LMNAPOLBSMN1; SMN2MAPTKMT2A | |
| SCHEMBL22831931 | 0.84 | LMNA (0.35) | LMNAPOLBSMN1; SMN2MAPTKMT2A | |
| SCHEMBL29562297 | 0.84 | LMNA (0.35) | LMNAPOLBSMN1; SMN2MAPTKMT2A | |
| SCHEMBL29562065 | 0.83 | LMNA (0.40) | LMNAPOLBSMN1; SMN2MAPTKMT2A | |
| SCHEMBL22831892 | 0.83 | LMNA (0.40) | LMNAPOLBSMN1; SMN2MAPTKMT2A | |
| SCHEMBL22831965 | 0.81 | LMNA (0.35) | LMNAPOLBSMN1; SMN2MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3990437-A1 | QUINAZOLIN-4-ONE DERIVATIVES USEFUL FOR THE TREATMENT OF BRAF-ASSOCIATED DISEASES AND DISORDERS | Array Biopharma, Inc. (US) | 2022-05-04 | — | — | EP | disclosed |