Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.42 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | CTSL | P07711 | 2/20 | 0.40 |
| ▸ | CTSS | P25774 | 1/20 | 0.40 |
| ▸ | CTSK | P43235 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22274051 | 0.75 | GAA (0.65) | KDM4EHPGDHSD17B10TSHRGAA | |
| SCHEMBL28873028 | 0.75 | KDM4E (0.75) | KDM4EHPGDHSD17B10TSHRGAA | |
| SCHEMBL28131577 | 0.71 | KDM4E (0.49) | KDM4EHPGDHSD17B10TSHRGAA | |
| SCHEMBL25302480 | 0.69 | KDM4E (0.47) | KDM4EHPGDHSD17B10TSHRKMT2A | |
| SCHEMBL29564372 | 0.67 | KDM4E (0.56) | KDM4EHPGDHSD17B10TSHRGAA | |
| SCHEMBL22279054 | 0.66 | KDM4E (0.57) | KDM4EHPGDHSD17B10TSHRGAA | |
| SCHEMBL6695035 | 0.66 | AURKA (0.50) | KDM4EHPGDHSD17B10TSHRPIK3CA | |
| SCHEMBL29456651 | 0.66 | KDM4E (0.73) | KDM4EHPGDHSD17B10TSHRGAA | |
| SCHEMBL16122033 | 0.65 | KDM4E (0.57) | KDM4EHPGDHSD17B10TSHRKMT2A | |
| SCHEMBL5593099 | 0.64 | KMO (0.44) | KDM4EHPGDHSD17B10TSHRKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109651297-B | N-benzyl-N-aryl sulfonamide derivative and preparation and application thereof | 杭州壹瑞医药科技有限公司 | 2022-05-27 | — | — | CN | disclosed |