Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.56 |
| ▸ | HPGD | P15428 | 3/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.56 |
| ▸ | TSHR | P16473 | 2/20 | 0.56 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR6 | P50406 | 1/20 | 0.41 |
| ▸ | BCL2 | P10415 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | RXRA | P19793 | 1/20 | 0.39 |
| ▸ | RXRB | P28702 | 1/20 | 0.39 |
| ▸ | RXRG | P48443 | 1/20 | 0.39 |
| ▸ | PRKACA | P17612 | 1/20 | 0.39 |
| ▸ | CDK8 | P49336 | 1/20 | 0.39 |
| ▸ | CLK2 | P49760 | 1/20 | 0.39 |
| ▸ | GSK3A | P49840 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | CDK9 | P50750 | 1/20 | 0.39 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.39 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22273612 | 0.75 | KDM4E (0.42) | KDM4EHPGDHSD17B10TSHRHTR2A | |
| SCHEMBL3475619 | 0.73 | KDM4E (1.00) | KDM4EHPGDHSD17B10TSHRHTR2A | |
| SCHEMBL10330188 | 0.71 | KDM4E (0.75) | KDM4EHPGDHSD17B10TSHRHTR2A | |
| SCHEMBL29456651 | 0.70 | KDM4E (0.73) | KDM4EHPGDHSD17B10TSHRHTR2A | |
| SCHEMBL29564375 | 0.67 | KDM4E (0.44) | KDM4EHPGDHSD17B10TSHRLRRK2 | |
| SCHEMBL13447402 | 0.66 | RXRA (0.72) | KDM4EHPGDHSD17B10TSHRPOLB | |
| SCHEMBL5123728 | 0.64 | RXRA (0.51) | KDM4EHPGDHSD17B10TSHRPOLB | |
| SCHEMBL4389194 | 0.63 | POLB (0.47) | HSD17B10POLBGSK3AGSK3BL3MBTL1 | |
| SCHEMBL28873028 | 0.63 | KDM4E (0.75) | KDM4EHPGDHSD17B10TSHRHTR2A | |
| SCHEMBL29152740 | 0.63 | MAPK1 (0.55) | KDM4EHPGDHSD17B10TSHRMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109651297-B | N-benzyl-N-aryl sulfonamide derivative and preparation and application thereof | 杭州壹瑞医药科技有限公司 | 2022-05-27 | — | — | CN | disclosed |