Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 5/20 | 0.36 |
| ▸ | LMNA | P02545 | 4/20 | 0.34 |
| ▸ | SRC | P12931 | 2/20 | 0.32 |
| ▸ | ZAP70 | P43403 | 2/20 | 0.32 |
| ▸ | SYK | P43405 | 2/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24674487 | 0.76 | LMNA (0.40) | LMNA | |
| SCHEMBL22714752 | 0.75 | PDE5A (0.36) | LMNA | |
| SCHEMBL22714228 | 0.75 | MAP4K4 (0.38) | MAP4K4SRCZAP70SYKCDK2 | |
| SCHEMBL24674519 | 0.74 | MAP4K4 (0.40) | MAP4K4 | |
| SCHEMBL29564025 | 0.69 | MAP4K4 (0.39) | MAP4K4LMNASRCZAP70SYK | |
| SCHEMBL22726096 | 0.68 | MAP4K4 (0.40) | MAP4K4LMNA | |
| SCHEMBL22714286 | 0.67 | LMNA (0.38) | LMNA | |
| SCHEMBL29564279 | 0.67 | LMNA (0.38) | LMNA | |
| SCHEMBL22715145 | 0.66 | LMNA (0.38) | LMNA | |
| SCHEMBL24469148 | 0.65 | P2RX3 (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3976609-A1 | PYRIDOPYRIMIDINES DERIVATIVES AS P2X3 INHIBITORS | Chiesi Farmaceutici S.p.A. (IT) | 2022-04-06 | — | — | EP | claimed |