SCHEMBL2956493

SCHEMBL2956493

Cc1ccnc(C=CC(=O)O)c1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 6/20 0.42
RAB9A P51151 6/20 0.42
NPC1 O15118 5/20 0.42
MAPT P10636 3/20 0.42
MEN1 O00255 2/20 0.42
KMT2A Q03164 2/20 0.42
HPGD P15428 2/20 0.42
NFKB1 P19838 1/20 0.42
NFKB2 Q00653 1/20 0.42
RELA Q04206 1/20 0.42
ALDH1A1 P00352 2/20 0.41
UHRF1 Q96T88 1/20 0.41
CCR1 P32246 1/20 0.41
CCR5 P51681 1/20 0.41
CCR8 P51685 1/20 0.41
KDM4E B2RXH2 2/20 0.40
LMNA P02545 2/20 0.40
HDAC3 O15379 2/20 0.40
HDAC4 P56524 2/20 0.40
HDAC1 Q13547 2/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2956488 1.00 SMN1; SMN2 (0.42) SMN1; SMN2RAB9ANPC1MAPTMEN1
SCHEMBL12501248 0.81 NPC1 (0.39) SMN1; SMN2RAB9ANPC1MAPTMEN1
SCHEMBL24805764 0.80 RAB9A (0.39) SMN1; SMN2RAB9ANPC1MAPTMEN1
SCHEMBL457578 0.79 TTR (0.49) SMN1; SMN2RAB9ANPC1MAPTLMNA
SCHEMBL457579 0.79 TTR (0.49) SMN1; SMN2RAB9ANPC1MAPTLMNA
SCHEMBL13964557 0.79 ITGB2 (0.42) SMN1; SMN2RAB9ANPC1MAPTMEN1
SCHEMBL9756942 0.79 KDM4E (0.50) SMN1; SMN2RAB9AMAPTMEN1KMT2A
SCHEMBL18989990 0.79 NPSR1 (0.50) RAB9AMAPTMEN1KMT2AHPGD
SCHEMBL18989993 0.79 NPSR1 (0.50) RAB9AMAPTMEN1KMT2AHPGD
SCHEMBL9756940 0.79 KDM4E (0.50) SMN1; SMN2RAB9AMAPTMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3211123-B1 HORIZONTAL METHOD OF ELECTROLESS METAL PLATING OF SUBSTRATES WITH IONIC CATALYSTS ROHM & HAAS ELECT MAT (US) 2019-01-09 EP claimed
US-20170251557-A1 HORIZONTAL METHOD OF ELECTROLESS METAL PLATING OF SUBSTRATES WITH IONIC CATALYSTS ROHM & HAAS ELECT MAT (US) 2017-08-31 US claimed
EP-3211123-A1 HORIZONTAL METHOD OF ELECTROLESS METAL PLATING OF SUBSTRATES WITH IONIC CATALYSTS Rohm and Haas Electronic Materials LLC (US) 2017-08-30 EP claimed
US-8591636-B2 Plating catalyst and method ROHM AND HAAS ELECTRONICS MATERIALS LLC (US) 2013-11-26 US claimed
EP-3211123-B1 HORIZONTAL METHOD OF ELECTROLESS METAL PLATING OF SUBSTRATES WITH IONIC CATALYSTS ROHM & HAAS ELECT MAT (US) 2019-01-09 EP disclosed
EP-2465974-B1 Plating catalyst and method ROHM & HAAS ELECT MAT (US) 2018-11-28 EP disclosed
US-20170251557-A1 HORIZONTAL METHOD OF ELECTROLESS METAL PLATING OF SUBSTRATES WITH IONIC CATALYSTS ROHM & HAAS ELECT MAT (US) 2017-08-31 US disclosed
EP-3211123-A1 HORIZONTAL METHOD OF ELECTROLESS METAL PLATING OF SUBSTRATES WITH IONIC CATALYSTS Rohm and Haas Electronic Materials LLC (US) 2017-08-30 EP disclosed
US-8961669-B2 Plating catalyst and method ROHM AND HAAS ELECTRONIC MATERIALS LLC (US) 2015-02-24 US disclosed
US-20140087062-A1 PLATING CATALYST AND METHOD ROHM & HAAS ELECT MAT (US) 2014-03-27 US disclosed
US-8591636-B2 Plating catalyst and method ROHM AND HAAS ELECTRONICS MATERIALS LLC (US) 2013-11-26 US disclosed
EP-2465974-A2 Plating catalyst and method Rohm and Haas Electronic Materials LLC (US) 2012-06-20 EP disclosed
US-20120145554-A1 PLATING CATALYST AND METHOD ROHM AND HAAS ELECTRONIC MATERIALS LLC (US) 2012-06-14 US disclosed
US-7767665-B2 3-[6-(4-oxo-4H-1,3-benzothiazin-2-yl)-2-pyridyl]propionic acid, having an excellent apoptosis inhibitory and Macrophage migration inhibitory factor (MIF) binding effects, used for preventing and/or treating cancers, AIDS, cardiovascular, neurodegeneartive, bone, kidney and liver disoders TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2010-08-03 US disclosed
US-20090082343-A1 1,3-BENZOTHIAZINONE DERIVATIVES AND USE THEREOF TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2009-03-26 US disclosed
US-7399759-B2 1, 3-benzothiazinone derivatives and use thereof TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2008-07-15 US disclosed
US-20050032786-A1 1, 3-benzothiazinone derivatives and use thereof TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2005-02-10 US disclosed
EP-1424336-A1 1,3-BENZOTHIAZINONE DERIVATIVES AND USE THEREOF Takeda Chemical Industries, Ltd. (JP) 2004-06-02 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090082343-A1 1,3-BENZOTHIAZINONE DERIVATIVES AND USE THEREOF MIF, MORF4L1, FOXM1 SMN1; SMN2 388/4885RAB9A 4678/4885NPC1 1326/4885
US-20050032786-A1 1, 3-benzothiazinone derivatives and use thereof MIF, MORF4L1, FOXM1 SMN1; SMN2 388/4885RAB9A 4678/4885NPC1 1326/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.