Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | PGR | P06401 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.36 |
| ▸ | TNKS | O95271 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | THPO | P40225 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | GMNN | O75496 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25313606 | 1.00 | MEN1 (0.39) | MEN1KMT2APGRSCN9ATNKS | |
| SCHEMBL25314259 | 0.90 | PGR (0.47) | MEN1KMT2APGRSCN9ATNKS | |
| SCHEMBL30132808 | 0.90 | PGR (0.47) | MEN1KMT2APGRSCN9ATNKS | |
| SCHEMBL30132793 | 0.82 | ALDH1A1 (0.42) | MEN1KMT2APGRTNKSALDH1A1 | |
| SCHEMBL25314511 | 0.82 | ALDH1A1 (0.42) | MEN1KMT2APGRTNKSALDH1A1 | |
| SCHEMBL25311893 | 0.79 | ALDH1A1 (0.33) | MEN1KMT2ASCN9AALDH1A1CYP2C19 | |
| SCHEMBL25312867 | 0.77 | MEN1 (0.34) | MEN1KMT2APGRSCN9A | |
| SCHEMBL23972244 | 0.77 | ALDH1A1 (0.38) | MEN1KMT2AALDH1A1CYP2C19CYP2D6 | |
| SCHEMBL24687985 | 0.77 | ALDH1A1 (0.38) | MEN1KMT2AALDH1A1CYP2C19CYP2D6 | |
| SCHEMBL30227489 | 0.77 | MEN1 (0.34) | MEN1KMT2APGRSCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4143182-A1 | NOVEL COMPOUNDS USEFUL AS POLY(ADP-RIBOSE) POLYMERASE (PARP) INHIBITORS | Rhizen Pharmaceuticals AG (CH) | 2023-03-08 | — | — | EP | disclosed |
| CN-115485271-A | Novel compounds as inhibitors of poly (ADP-ribose) polymerase (PARP) | 理森制药股份公司 | 2022-12-16 | — | — | CN | disclosed |
| WO-2022090938-A1 | PHTHALAZINONE DERIVATIVES USEFUL AS PARP INHIBITORS | RHIZEN PHARMACEUTICALS AG (CH) | 2022-05-05 | — | — | WO | disclosed |