Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 17/20 | 0.50 |
| ▸ | JAK3 | P52333 | 17/20 | 0.50 |
| ▸ | JAK1 | P23458 | 13/20 | 0.50 |
| ▸ | JAK2 | O60674 | 13/20 | 0.50 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.44 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.44 |
| ▸ | AURKA | O14965 | 2/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.44 |
| ▸ | GSK3B | P49841 | 2/20 | 0.43 |
| ▸ | GSK3A | P49840 | 1/20 | 0.43 |
| ▸ | SRC | P12931 | 1/20 | 0.42 |
| ▸ | AURKC | Q9UQB9 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29565789 | 0.89 | TYK2 (0.52) | TYK2JAK3JAK1JAK2P2RX3 | |
| Hydrochloric Acid SCHEMBL29565580 | 0.88 | TYK2 (0.51) | TYK2JAK3JAK1JAK2P2RX3 | |
| Trifluoroacetic Acid SCHEMBL28979015 | 0.80 | TYK2 (0.64) | TYK2JAK3JAK1JAK2P2RX3 | |
| Trifluoroacetic Acid SCHEMBL28978676 | 0.79 | TYK2 (0.66) | TYK2JAK3JAK1JAK2P2RX3 | |
| Trifluoroacetic Acid SCHEMBL28978706 | 0.76 | JAK3 (0.54) | TYK2JAK3JAK1JAK2P2RX3 | |
| Trifluoroacetic Acid SCHEMBL28978686 | 0.76 | TYK2 (0.51) | TYK2JAK3JAK1JAK2P2RX3 | |
| Trifluoroacetic Acid SCHEMBL28978695 | 0.76 | JAK3 (0.60) | TYK2JAK3JAK1JAK2P2RX3 | |
| SCHEMBL23889351 | 0.74 | TYK2 (0.58) | TYK2JAK3JAK1JAK2P2RX3 | |
| Trifluoroacetic Acid SCHEMBL29565800 | 0.74 | TYK2 (0.35) | TYK2JAK3JAK1JAK2AURKA | |
| SCHEMBL24175050 | 0.73 | TYK2 (0.49) | TYK2JAK3JAK1JAK2P2RX3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111362975-B | Naphthyridine compounds as JAK kinase inhibitors | 施万生物制药研发IP有限责任公司 | 2022-04-05 | — | — | CN | disclosed |