Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 4/20 | 0.35 |
| ▸ | JAK3 | P52333 | 4/20 | 0.35 |
| ▸ | AURKA | O14965 | 11/20 | 0.35 |
| ▸ | JAK1 | P23458 | 3/20 | 0.34 |
| ▸ | JAK2 | O60674 | 2/20 | 0.34 |
| ▸ | AURKB | Q96GD4 | 9/20 | 0.34 |
| ▸ | S1PR4 | O95977 | 3/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 3/20 | 0.33 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.33 |
| ▸ | SRC | P12931 | 2/20 | 0.33 |
| ▸ | GSK3B | P49841 | 2/20 | 0.33 |
| ▸ | AURKC | Q9UQB9 | 1/20 | 0.33 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29565542 | 0.92 | AURKA (0.39) | TYK2JAK3AURKAJAK1JAK2 | |
| Trifluoroacetic Acid SCHEMBL29565798 | 0.74 | TYK2 (0.50) | TYK2JAK3AURKAJAK1JAK2 | |
| SCHEMBL29566641 | 0.71 | NR1I2 (0.34) | — | |
| Trifluoroacetic Acid SCHEMBL29566493 | 0.63 | MAPT (0.37) | GSK3B | |
| Trifluoroacetic Acid SCHEMBL29566185 | 0.63 | MAPT (0.37) | GSK3B | |
| Trifluoroacetic Acid SCHEMBL28416274 | 0.63 | MAPT (0.37) | GSK3B | |
| SCHEMBL29565789 | 0.63 | TYK2 (0.52) | TYK2JAK3AURKAJAK1JAK2 | |
| Hydrochloric Acid SCHEMBL29565580 | 0.62 | TYK2 (0.51) | TYK2JAK3AURKAJAK1JAK2 | |
| SCHEMBL30382152 | 0.62 | P2RX7 (0.40) | — | |
| SCHEMBL30604094 | 0.60 | KDM4E (0.56) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111362975-B | Naphthyridine compounds as JAK kinase inhibitors | 施万生物制药研发IP有限责任公司 | 2022-04-05 | — | — | CN | disclosed |