Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | AR | P10275 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | PGR | P06401 | 1/20 | 0.39 |
| ▸ | NFKBIA | P25963 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | DDX3X | O00571 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | EDNRA | P25101 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.38 |
| ▸ | TYMS | P04818 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29566848 | 0.86 | POLB (0.37) | ALDH1A1MAPTCYP19A1 | |
| SCHEMBL26806781 | 0.86 | POLB (0.37) | ALDH1A1MAPTCYP19A1 | |
| SCHEMBL29567669 | 0.85 | LMNA (0.45) | LMNAALDH1A1KDM4EMAPTAR | |
| SCHEMBL26806595 | 0.82 | LMNA (0.47) | LMNAALDH1A1KDM4EMAPTMEN1 | |
| SCHEMBL29566410 | 0.81 | LMNA (0.49) | LMNAALDH1A1KDM4EMAPTMEN1 | |
| SCHEMBL26806638 | 0.81 | LMNA (0.49) | LMNAALDH1A1KDM4EMAPTMEN1 | |
| SCHEMBL29566406 | 0.81 | LMNA (0.49) | LMNAALDH1A1KDM4EMAPTMEN1 | |
| SCHEMBL26806641 | 0.81 | LMNA (0.49) | LMNAALDH1A1KDM4EMAPTMEN1 | |
| SCHEMBL26806784 | 0.75 | POLB (0.41) | LMNAALDH1A1KDM4EMAPTKMT2A | |
| SCHEMBL24309602 | 0.74 | PGR (0.56) | LMNAALDH1A1KDM4EMAPTAR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4225748-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | Vertex Pharmaceuticals Incorporated (US) | 2023-08-16 | — | — | EP | disclosed |
| WO-2022076627-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-04-14 | — | — | WO | disclosed |