Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | CDK1 | P06493 | 1/20 | 0.37 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.36 |
| ▸ | PIK3C2G | O75747 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 3/20 | 0.35 |
| ▸ | HTR1A | P08908 | 6/20 | 0.34 |
| ▸ | HTR7 | P34969 | 6/20 | 0.34 |
| ▸ | DRD2 | P14416 | 2/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.34 |
| ▸ | F2 | P00734 | 1/20 | 0.34 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26806781 | 1.00 | POLB (0.37) | POLBCDK1CCNA2CDK2CCNA1 | |
| SCHEMBL26806784 | 0.89 | POLB (0.41) | POLBMAPTPIK3C2BPIK3C2GSMN1; SMN2 | |
| SCHEMBL29566361 | 0.86 | LMNA (0.41) | MAPTALDH1A1CYP19A1 | |
| SCHEMBL26806783 | 0.85 | POLB (0.41) | POLBMAPTPIK3C2BPIK3C2GSMN1; SMN2 | |
| SCHEMBL26806794 | 0.85 | POLB (0.38) | POLBMAPTPIK3C2BPIK3C2GSMN1; SMN2 | |
| SCHEMBL26806787 | 0.85 | PTGS1 (0.40) | POLBMAPTPIK3C2BPIK3C2GSMN1; SMN2 | |
| SCHEMBL26806726 | 0.84 | POLB (0.43) | POLBMAPTPIK3C2BPIK3C2GSMN1; SMN2 | |
| SCHEMBL24309523 | 0.83 | POLB (0.36) | POLBMAPTPIK3C2BPIK3C2GSMN1; SMN2 | |
| SCHEMBL29566755 | 0.83 | POLB (0.36) | POLBMAPTPIK3C2BPIK3C2GSMN1; SMN2 | |
| SCHEMBL26806791 | 0.83 | POLB (0.36) | POLBMAPTPIK3C2BPIK3C2GSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4225748-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | Vertex Pharmaceuticals Incorporated (US) | 2023-08-16 | — | — | EP | disclosed |
| WO-2022076627-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-04-14 | — | — | WO | disclosed |