Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 5/20 | 0.39 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 9/20 | 0.35 |
| ▸ | HTR2A | P28223 | 2/20 | 0.35 |
| ▸ | MAP4K1 | Q92918 | 3/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 1/20 | 0.34 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | HTR7 | P34969 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | INSR | P06213 | 1/20 | 0.33 |
| ▸ | MET | P08581 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26809820 | 1.00 | BRD4 (0.39) | BRD4TNK2HTR6HTR2AMAP4K1 | |
| SCHEMBL26809792 | 0.91 | HTR6 (0.37) | BRD4TNK2HTR6HTR2AMAP4K1 | |
| SCHEMBL29567125 | 0.91 | HTR6 (0.37) | BRD4TNK2HTR6HTR2AMAP4K1 | |
| SCHEMBL29566394 | 0.90 | BRD4 (0.36) | BRD4TNK2HTR6MAP4K1JAK1 | |
| SCHEMBL24309421 | 0.90 | BRD4 (0.36) | BRD4TNK2HTR6MAP4K1JAK1 | |
| SCHEMBL29566817 | 0.88 | EGFR (0.37) | BRD4TNK2MAP4K1JAK3EGFR | |
| SCHEMBL24309686 | 0.88 | EGFR (0.37) | BRD4TNK2MAP4K1JAK3EGFR | |
| SCHEMBL24309753 | 0.86 | HTR6 (0.41) | BRD4TNK2HTR6HTR2AHTR1A | |
| SCHEMBL29567208 | 0.86 | HTR6 (0.41) | BRD4TNK2HTR6HTR2AHTR1A | |
| SCHEMBL24309515 | 0.85 | BRD4 (0.47) | BRD4HTR6MAP4K1HTR1AHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4225748-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | Vertex Pharmaceuticals Incorporated (US) | 2023-08-16 | — | — | EP | disclosed |
| WO-2022076627-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-04-14 | — | — | WO | disclosed |