Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 8/20 | 0.37 |
| ▸ | BRD4 | O60885 | 4/20 | 0.36 |
| ▸ | HTR1A | P08908 | 2/20 | 0.35 |
| ▸ | DRD2 | P14416 | 2/20 | 0.35 |
| ▸ | DRD3 | P35462 | 2/20 | 0.35 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HTR7 | P34969 | 1/20 | 0.33 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26809792 | 1.00 | HTR6 (0.37) | HTR6BRD4HTR1ADRD2DRD3 | |
| SCHEMBL24309255 | 0.92 | DRD2 (0.36) | HTR6BRD4HTR1ADRD2DRD4 | |
| SCHEMBL29566539 | 0.92 | DRD2 (0.36) | HTR6BRD4HTR1ADRD2DRD4 | |
| SCHEMBL29566472 | 0.91 | BRD4 (0.39) | HTR6BRD4HTR1AHTR2AMAP4K1 | |
| SCHEMBL26809820 | 0.91 | BRD4 (0.39) | HTR6BRD4HTR1AHTR2AMAP4K1 | |
| SCHEMBL29567119 | 0.89 | HTR6 (0.42) | HTR6HTR1ADRD2DRD3DRD4 | |
| SCHEMBL24309421 | 0.88 | BRD4 (0.36) | HTR6BRD4HTR1AMAP4K1TNK2 | |
| SCHEMBL29566394 | 0.88 | BRD4 (0.36) | HTR6BRD4HTR1AMAP4K1TNK2 | |
| SCHEMBL24309442 | 0.88 | BRD4 (0.37) | HTR6BRD4HTR1ADRD3HTR2A | |
| SCHEMBL29566947 | 0.88 | BRD4 (0.37) | HTR6BRD4HTR1ADRD3HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4225748-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | Vertex Pharmaceuticals Incorporated (US) | 2023-08-16 | — | — | EP | disclosed |
| WO-2022076627-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-04-14 | — | — | WO | disclosed |