Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 10/20 | 0.41 |
| ▸ | HTR7 | P34969 | 9/20 | 0.41 |
| ▸ | HTR1A | P08908 | 8/20 | 0.41 |
| ▸ | DRD2 | P14416 | 4/20 | 0.41 |
| ▸ | HTR2A | P28223 | 7/20 | 0.36 |
| ▸ | HTR2C | P28335 | 3/20 | 0.34 |
| ▸ | BRD4 | O60885 | 2/20 | 0.34 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.33 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | APAF1 | O14727 | 1/20 | 0.33 |
| ▸ | MITF | O75030 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24309753 | 1.00 | HTR6 (0.41) | HTR6HTR7HTR1ADRD2HTR2A | |
| SCHEMBL29567213 | 0.91 | DRD2 (0.41) | HTR6HTR7HTR1ADRD2HTR2A | |
| SCHEMBL26808351 | 0.88 | HTR1A (0.40) | HTR6HTR7HTR1ADRD2HTR2A | |
| SCHEMBL26808374 | 0.86 | HTR1A (0.44) | HTR6HTR7HTR1ADRD2HTR2A | |
| SCHEMBL29566472 | 0.86 | BRD4 (0.39) | HTR6HTR7HTR1AHTR2ABRD4 | |
| SCHEMBL26809820 | 0.86 | BRD4 (0.39) | HTR6HTR7HTR1AHTR2ABRD4 | |
| SCHEMBL29566934 | 0.85 | HTR7 (0.39) | HTR6HTR7HTR1ADRD2HTR2A | |
| SCHEMBL24310020 | 0.85 | HTR7 (0.39) | HTR6HTR7HTR1ADRD2HTR2A | |
| SCHEMBL26808353 | 0.83 | HTR1A (0.39) | HTR6HTR7HTR1ADRD2HTR2A | |
| SCHEMBL24309255 | 0.81 | DRD2 (0.36) | HTR6HTR7HTR1ADRD2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4225748-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | Vertex Pharmaceuticals Incorporated (US) | 2023-08-16 | — | — | EP | disclosed |
| WO-2022076627-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-04-14 | — | — | WO | disclosed |