Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1I2 | O75469 | 1/20 | 0.34 |
| ▸ | TLR8 | Q9NR97 | 14/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.33 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.33 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29565542 | 0.78 | AURKA (0.39) | — | |
| SCHEMBL22684510 | 0.74 | MCHR1 (0.40) | NR1I2TLR8KCNH2 | |
| SCHEMBL10713325 | 0.70 | LTB4R (0.39) | NR1I2 | |
| SCHEMBL13300320 | 0.69 | TLR8 (0.45) | TLR8TLR7KCNH2 | |
| SCHEMBL30749411 | 0.69 | NR1I2 (0.36) | NR1I2 | |
| SCHEMBL21095856 | 0.68 | TLR8 (0.40) | TLR8TLR7 | |
| SCHEMBL20989341 | 0.68 | TSHR (0.43) | NR1I2KCNH2 | |
| SCHEMBL24971835 | 0.67 | MCHR1 (0.42) | NR1I2TLR8KCNH2 | |
| SCHEMBL19518873 | 0.67 | MCHR1 (0.42) | NR1I2TLR8KCNH2 | |
| SCHEMBL19772965 | 0.66 | NR1I2 (0.37) | NR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111362975-B | Naphthyridine compounds as JAK kinase inhibitors | 施万生物制药研发IP有限责任公司 | 2022-04-05 | — | — | CN | disclosed |