Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 11/20 | 0.39 |
| ▸ | TYK2 | P29597 | 7/20 | 0.36 |
| ▸ | JAK3 | P52333 | 7/20 | 0.36 |
| ▸ | JAK1 | P23458 | 6/20 | 0.35 |
| ▸ | JAK2 | O60674 | 4/20 | 0.35 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.34 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.33 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL29565800 | 0.92 | TYK2 (0.35) | AURKATYK2JAK3JAK1JAK2 | |
| SCHEMBL29566641 | 0.78 | NR1I2 (0.34) | — | |
| SCHEMBL29565789 | 0.69 | TYK2 (0.52) | AURKATYK2JAK3JAK1JAK2 | |
| Hydrochloric Acid SCHEMBL29565580 | 0.68 | TYK2 (0.51) | AURKATYK2JAK3JAK1JAK2 | |
| SCHEMBL22815348 | 0.64 | CYP1A2 (0.39) | AURKA | |
| SCHEMBL22815352 | 0.64 | CYP1A2 (0.39) | AURKA | |
| SCHEMBL19362661 | 0.64 | CYP1A2 (0.39) | AURKA | |
| Trifluoroacetic Acid SCHEMBL29565798 | 0.61 | TYK2 (0.50) | AURKATYK2JAK3JAK1JAK2 | |
| SCHEMBL30382152 | 0.61 | P2RX7 (0.40) | — | |
| SCHEMBL22684510 | 0.61 | MCHR1 (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111362975-B | Naphthyridine compounds as JAK kinase inhibitors | 施万生物制药研发IP有限责任公司 | 2022-04-05 | — | — | CN | disclosed |