Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACVR1 | Q04771 | 6/20 | 0.39 |
| ▸ | RIPK2 | O43353 | 4/20 | 0.39 |
| ▸ | NOD2 | Q9HC29 | 4/20 | 0.39 |
| ▸ | GUSB | P08236 | 4/20 | 0.37 |
| ▸ | HTR6 | P50406 | 2/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.36 |
| ▸ | FLT3 | P36888 | 1/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.35 |
| ▸ | LTA4H | P09960 | 1/20 | 0.35 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CDK4 | P11802 | 1/20 | 0.33 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.33 |
| ▸ | CCND1 | P24385 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | CCND2 | P30279 | 1/20 | 0.33 |
| ▸ | CCND3 | P30281 | 1/20 | 0.33 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24310301 | 0.90 | GUSB (0.37) | ACVR1RIPK2NOD2GUSBHTR6 | |
| SCHEMBL29566475 | 0.90 | GUSB (0.37) | ACVR1RIPK2NOD2GUSBHTR6 | |
| SCHEMBL29566726 | 0.89 | RIPK2 (0.39) | ACVR1RIPK2NOD2GUSBHTR6 | |
| SCHEMBL26807316 | 0.89 | RIPK2 (0.39) | ACVR1RIPK2NOD2GUSBHTR6 | |
| SCHEMBL26807468 | 0.88 | GUSB (0.42) | ACVR1RIPK2NOD2GUSBHTR6 | |
| SCHEMBL26808355 | 0.87 | HTR6 (0.39) | ACVR1RIPK2NOD2GUSBHTR6 | |
| SCHEMBL26807460 | 0.86 | HTR6 (0.43) | ACVR1RIPK2NOD2GUSBHTR6 | |
| SCHEMBL26807466 | 0.86 | FLT3 (0.38) | ACVR1RIPK2NOD2GUSBHTR6 | |
| SCHEMBL26807780 | 0.85 | LTA4H (0.47) | ACVR1RIPK2NOD2GUSBHTR6 | |
| SCHEMBL29566429 | 0.85 | RIPK2 (0.37) | ACVR1RIPK2NOD2GUSBHTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230373935-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS, SAN DIEGO | 2023-11-23 | — | — | US | disclosed |
| US-20230373935-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS, SAN DIEGO | 2023-11-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230373935-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | CFTR, SCNN1G, SCNN1B | ACVR1 1319/4885RIPK2 3698/4885NOD2 724/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.