Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 2/20 | 0.33 |
| ▸ | KDR | P35968 | 2/20 | 0.33 |
| ▸ | MET | P08581 | 1/20 | 0.33 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | TSPO | P30536 | 1/20 | 0.31 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.31 |
| ▸ | EGFR | P00533 | 1/20 | 0.31 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24310798 | 1.00 | BRD4 (0.33) | BRD4KDRMETPTGDR2GAA | |
| SCHEMBL26810204 | 0.90 | PDE4B (0.39) | BRD4KDRMETGAATSHR | |
| SCHEMBL29566776 | 0.90 | F2 (0.38) | KDRMETPTGDR2TSHRSMN1; SMN2 | |
| SCHEMBL24309560 | 0.90 | F2 (0.38) | KDRMETPTGDR2TSHRSMN1; SMN2 | |
| SCHEMBL24310203 | 0.89 | MEN1 (0.38) | BRD4KDRPTGDR2HSD11B1SMN1; SMN2 | |
| SCHEMBL26810202 | 0.88 | LMNA (0.36) | BRD4KDRMETGAATSHR | |
| SCHEMBL26810067 | 0.86 | ALDH1A1 (0.37) | BRD4GAATSHRSMN1; SMN2LMNA | |
| SCHEMBL26810198 | 0.86 | HSD17B10 (0.40) | BRD4GAAHSD11B1SMN1; SMN2POLB | |
| SCHEMBL24309561 | 0.85 | KMT2A (0.31) | KDRMETLMNAKMT2AALDH1A1 | |
| SCHEMBL24310129 | 0.85 | GAA (0.41) | GAAHSD11B1POLBMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4225748-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | Vertex Pharmaceuticals Incorporated (US) | 2023-08-16 | — | — | EP | disclosed |
| WO-2022076627-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-04-14 | — | — | WO | disclosed |