Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | PGR | P06401 | 1/20 | 0.48 |
| ▸ | NFKBIA | P25963 | 1/20 | 0.48 |
| ▸ | RELA | Q04206 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | EDNRA | P25101 | 2/20 | 0.47 |
| ▸ | DDX3X | O00571 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | FBP1 | P09467 | 1/20 | 0.46 |
| ▸ | EDNRB | P24530 | 1/20 | 0.45 |
| ▸ | KDM1A | O60341 | 1/20 | 0.45 |
| ▸ | AR | P10275 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24309251 | 1.00 | LMNA (0.52) | LMNAPGRNFKBIARELAALDH1A1 | |
| SCHEMBL24309260 | 0.87 | LMNA (0.49) | LMNAPGRNFKBIARELAALDH1A1 | |
| SCHEMBL29566397 | 0.87 | LMNA (0.49) | LMNAPGRNFKBIARELAALDH1A1 | |
| SCHEMBL29566547 | 0.87 | LMNA (0.51) | LMNAPGRNFKBIARELAALDH1A1 | |
| SCHEMBL24309308 | 0.87 | LMNA (0.51) | LMNAPGRNFKBIARELAALDH1A1 | |
| SCHEMBL24309294 | 0.85 | PGR (0.64) | LMNAPGRNFKBIARELAALDH1A1 | |
| SCHEMBL29566554 | 0.85 | PGR (0.64) | LMNAPGRNFKBIARELAALDH1A1 | |
| SCHEMBL24298639 | 0.84 | ALDH1A1 (0.60) | LMNAPGRNFKBIARELAALDH1A1 | |
| SCHEMBL29567052 | 0.84 | ALDH1A1 (0.60) | LMNAPGRNFKBIARELAALDH1A1 | |
| SCHEMBL24330660 | 0.82 | LMNA (0.55) | LMNANFKBIARELAALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4225748-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | Vertex Pharmaceuticals Incorporated (US) | 2023-08-16 | — | — | EP | disclosed |
| WO-2022076627-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-04-14 | — | — | WO | disclosed |