Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | PLA2G7 | Q13093 | 2/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 5/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.41 |
| ▸ | PIK3C2G | O75747 | 1/20 | 0.41 |
| ▸ | IDH1 | O75874 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24309588 | 1.00 | PKM (0.49) | PKMPLA2G7ATMLMNAMAPT | |
| SCHEMBL26807087 | 0.92 | PKM (0.50) | PKMPLA2G7ATMLMNAMAPT | |
| SCHEMBL26807176 | 0.88 | PLA2G7 (0.46) | PKMPLA2G7ATMLMNAMAPT | |
| SCHEMBL26810957 | 0.86 | TSHR (0.54) | PKMLMNAMAPTALDH1A1KMT2A | |
| SCHEMBL24309603 | 0.84 | POLB (0.45) | PKMLMNAMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL26811070 | 0.82 | PLA2G7 (0.46) | PLA2G7LMNAMAPTMEN1KMT2A | |
| SCHEMBL24309602 | 0.80 | PGR (0.56) | LMNAMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL29568117 | 0.80 | PGR (0.56) | LMNAMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL24309592 | 0.80 | NPC1 (0.37) | LMNAMAPTALDH1A1MEN1MAPK1 | |
| SCHEMBL26807160 | 0.80 | CA12 (0.41) | LMNAMAPTALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4225748-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | Vertex Pharmaceuticals Incorporated (US) | 2023-08-16 | — | — | EP | disclosed |
| WO-2022076627-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-04-14 | — | — | WO | disclosed |