Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 2/20 | 0.37 |
| ▸ | HTR1B | P28222 | 2/20 | 0.37 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.37 |
| ▸ | HTR6 | P50406 | 3/20 | 0.36 |
| ▸ | BRD4 | O60885 | 6/20 | 0.36 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | HTR7 | P34969 | 1/20 | 0.34 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.34 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26809817 | 1.00 | HTR1D (0.37) | HTR1DHTR1BDGAT2HTR6BRD4 | |
| SCHEMBL24309786 | 0.96 | DGAT2 (0.40) | DGAT2HTR6BRD4HRH4MAP4K1 | |
| SCHEMBL26808238 | 0.91 | DGAT2 (0.36) | DGAT2HTR6BRD4HTR1AHTR2A | |
| SCHEMBL24310534 | 0.89 | DGAT2 (0.35) | DGAT2HTR6BRD4HTR1AHTR2A | |
| SCHEMBL29567043 | 0.88 | HTR6 (0.37) | HTR1DHTR1BHTR6HTR1AHTR2A | |
| SCHEMBL26837336 | 0.88 | HTR6 (0.37) | HTR1DHTR1BHTR6HTR1AHTR2A | |
| SCHEMBL24309946 | 0.88 | MAP4K1 (0.38) | DGAT2HTR6BRD4HTR1AHTR2A | |
| SCHEMBL24310014 | 0.88 | HTR1A (0.42) | HTR6BRD4HTR1AHTR2AHTR7 | |
| SCHEMBL29567227 | 0.88 | MAP4K1 (0.43) | DGAT2HTR6BRD4HTR1AHTR2A | |
| SCHEMBL24310343 | 0.88 | MAP4K1 (0.43) | DGAT2HTR6BRD4HTR1AHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4225748-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | Vertex Pharmaceuticals Incorporated (US) | 2023-08-16 | — | — | EP | disclosed |
| WO-2022076627-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-04-14 | — | — | WO | disclosed |