Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 1/20 | 0.33 |
| ▸ | BRAF | P15056 | 1/20 | 0.32 |
| ▸ | TACR1 | P25103 | 2/20 | 0.32 |
| ▸ | BRD4 | O60885 | 3/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | FLT3 | P36888 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
| ▸ | JAK3 | P52333 | 1/20 | 0.32 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 2/20 | 0.31 |
| ▸ | MET | P08581 | 2/20 | 0.31 |
| ▸ | INSR | P06213 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24310787 | 1.00 | AXL (0.33) | AXLBRAFTACR1BRD4JAK2 | |
| SCHEMBL24310777 | 0.90 | HTR1A (0.38) | TACR1BRD4JAK2JAK3EGFR | |
| SCHEMBL29566715 | 0.90 | HTR1A (0.38) | TACR1BRD4JAK2JAK3EGFR | |
| SCHEMBL29566963 | 0.89 | RAD52 (0.36) | TACR1BRD4JAK2FLT3JAK1 | |
| SCHEMBL24310187 | 0.89 | RAD52 (0.36) | TACR1BRD4JAK2FLT3JAK1 | |
| SCHEMBL24310497 | 0.88 | RAD52 (0.36) | BRD4JAK3EGFRMETINSR | |
| SCHEMBL29566997 | 0.88 | RAD52 (0.34) | TACR1BRD4JAK2ALDH1A1TP53 | |
| SCHEMBL24310530 | 0.88 | RAD52 (0.34) | TACR1BRD4JAK2ALDH1A1TP53 | |
| SCHEMBL29567137 | 0.88 | RAD52 (0.36) | BRD4JAK3EGFRMETINSR | |
| SCHEMBL29567138 | 0.88 | RAD52 (0.36) | BRD4JAK3EGFRMETINSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4225748-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | Vertex Pharmaceuticals Incorporated (US) | 2023-08-16 | — | — | EP | disclosed |
| WO-2022076627-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-04-14 | — | — | WO | disclosed |