Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 5/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22905581 | 1.00 | POLB (0.60) | POLBTSHRCA2HPGDL3MBTL1 | |
| SCHEMBL22905481 | 0.78 | POLB (0.37) | POLBCA2L3MBTL1NPC1SMN1; SMN2 | |
| SCHEMBL22905676 | 0.76 | CA2 (0.34) | POLBCA2 | |
| SCHEMBL22905422 | 0.72 | POLB (0.59) | POLBTSHRHPGDL3MBTL1NPC1 | |
| SCHEMBL22905655 | 0.72 | NLRP3 (0.56) | CA2 | |
| SCHEMBL22905495 | 0.72 | NLRP3 (0.56) | CA2 | |
| SCHEMBL22905512 | 0.71 | POLB (0.58) | POLBTSHRHPGDL3MBTL1NPC1 | |
| SCHEMBL22905548 | 0.71 | POLB (0.44) | POLBCA2 | |
| SCHEMBL22905580 | 0.70 | CDC7 (0.40) | CA2L3MBTL1LMNAMAPK1 | |
| SCHEMBL24774207 | 0.69 | NLRP3 (0.52) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114555571-B | N- ((1, 2,3,5,6, 7-hexahydro-s-indacen-4-yl) carbamoyl) -4,5,6, 7-tetrahydrobenzofuran-2-sulfonamide derivatives as NLRP3 modulators | 祖玛珍生物科学有限公司 | 2024-08-27 | — | — | CN | disclosed |
| CN-114555571-A | N- ((1,2,3,5,6, 7-hexahydro-s-indacen-4-yl) carbamoyl) -4,5,6, 7-tetrahydrobenzofuran-2-sulfonamide derivatives and related compounds as NLPR3 modulators for the treatment of Multiple Sclerosis (MS) | 祖玛珍生物科学有限公司 | 2022-05-27 | — | — | CN | disclosed |