Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 3/20 | 0.39 |
| ▸ | HTR1A | P08908 | 2/20 | 0.39 |
| ▸ | HTR2A | P28223 | 2/20 | 0.39 |
| ▸ | HTR2C | P28335 | 2/20 | 0.39 |
| ▸ | HTR7 | P34969 | 2/20 | 0.39 |
| ▸ | DRD3 | P35462 | 2/20 | 0.39 |
| ▸ | RAD52 | P43351 | 2/20 | 0.38 |
| ▸ | BRD4 | O60885 | 10/20 | 0.37 |
| ▸ | EGFR | P00533 | 3/20 | 0.37 |
| ▸ | CCNK | O75909 | 1/20 | 0.35 |
| ▸ | CCND3 | P30281 | 1/20 | 0.35 |
| ▸ | CDK9 | P50750 | 1/20 | 0.35 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24309465 | 1.00 | HTR6 (0.39) | HTR6HTR1AHTR2AHTR2CHTR7 | |
| SCHEMBL29566903 | 0.94 | HTR1A (0.39) | HTR6HTR1AHTR2AHTR2CHTR7 | |
| SCHEMBL24310456 | 0.94 | HTR1A (0.39) | HTR6HTR1AHTR2AHTR2CHTR7 | |
| SCHEMBL24309591 | 0.91 | HTR6 (0.37) | HTR6HTR1AHTR2AHTR2CHTR7 | |
| SCHEMBL26806747 | 0.89 | HTR2C (0.43) | HTR6HTR1AHTR2AHTR2CHTR7 | |
| SCHEMBL26806745 | 0.89 | HTR2C (0.42) | HTR6HTR1AHTR2AHTR2CHTR7 | |
| SCHEMBL26806717 | 0.89 | HTR2C (0.46) | HTR6HTR1AHTR2AHTR2CHTR7 | |
| SCHEMBL26806697 | 0.89 | HTR1A (0.37) | HTR6HTR1AHTR2AHTR2CHTR7 | |
| SCHEMBL29566615 | 0.88 | HTR6 (0.36) | HTR6HTR1AHTR2AHTR2CHTR7 | |
| SCHEMBL26806614 | 0.88 | HTR6 (0.36) | HTR6HTR1AHTR2AHTR2CHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4225748-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | Vertex Pharmaceuticals Incorporated (US) | 2023-08-16 | — | — | EP | disclosed |
| WO-2022076627-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-04-14 | — | — | WO | disclosed |