Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 13/20 | 0.36 |
| ▸ | HTR7 | P34969 | 5/20 | 0.36 |
| ▸ | HTR1A | P08908 | 4/20 | 0.36 |
| ▸ | HTR2A | P28223 | 3/20 | 0.36 |
| ▸ | HTR2C | P28335 | 3/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 4/20 | 0.35 |
| ▸ | APAF1 | O14727 | 1/20 | 0.34 |
| ▸ | MITF | O75030 | 1/20 | 0.34 |
| ▸ | DRD1 | P21728 | 2/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.34 |
| ▸ | DRD4 | P21917 | 1/20 | 0.34 |
| ▸ | DRD5 | P21918 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26806614 | 1.00 | HTR6 (0.36) | HTR6HTR7HTR1AHTR2AHTR2C | |
| SCHEMBL24309591 | 0.91 | HTR6 (0.37) | HTR6HTR7HTR1AHTR2AHTR2C | |
| SCHEMBL26806704 | 0.89 | SCN9A (0.36) | HTR6HTR7HTR1AHTR2AHTR2C | |
| SCHEMBL29567213 | 0.88 | DRD2 (0.41) | HTR6HTR7HTR1AHTR2AHTR2C | |
| SCHEMBL29567849 | 0.88 | HTR6 (0.39) | HTR6HTR7HTR1AHTR2AHTR2C | |
| SCHEMBL26806762 | 0.88 | HTR6 (0.38) | HTR6HTR7HTR1AHTR2AHTR2C | |
| SCHEMBL29566903 | 0.88 | HTR1A (0.39) | HTR6HTR7HTR1AHTR2AHTR2C | |
| SCHEMBL24309465 | 0.88 | HTR6 (0.39) | HTR6HTR7HTR1AHTR2AHTR2C | |
| SCHEMBL24310456 | 0.88 | HTR1A (0.39) | HTR6HTR7HTR1AHTR2AHTR2C | |
| SCHEMBL26806712 | 0.88 | APAF1 (0.41) | HTR6HTR7HTR1AHTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4225748-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | Vertex Pharmaceuticals Incorporated (US) | 2023-08-16 | — | — | EP | disclosed |
| WO-2022076627-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-04-14 | — | — | WO | disclosed |