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Tryptophan

Tryptophan

SCHEMBL295705

CSCC[C@H](N)C(=O)O.C[C@@H](O)[C@H](N)C(=O)OC(=O)[C@@H](N)CC(N)=O.C[C@H](N)C(=O)O.N[C@@H](CC(=O)O)C(=O)O.N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O.N[C@@H](Cc1ccc(O)cc1)C(=O)O.N[C@@H](Cc1ccccc1)C(=O)O

nearest known ligand 0.43

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

SSTR1SSTR2SSTR3SSTR5

The experimentally established mechanism targets of Tryptophan. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
▸ KDM4E B2RXH2 1/20 0.43
▸ MEN1 O00255 1/20 0.43
▸ LMNA P02545 1/20 0.43
▸ MPO P05164 1/20 0.43
▸ MAPT P10636 1/20 0.43
▸ TSHR P16473 1/20 0.43
▸ BLM P54132 1/20 0.43
▸ PMP22 Q01453 1/20 0.43
▸ KMT2A Q03164 1/20 0.43
▸ HIF1A Q16665 1/20 0.43
▸ CCKBR P32239 13/20 0.42
▸ CCKAR P32238 2/20 0.41
▸ OPRM1 P35372 2/20 0.41
▸ OPRD1 P41143 2/20 0.41
▸ CTSC P53634 2/20 0.41
▸ IL1RN P18510 1/20 0.39
▸ ERAP2 Q6P179 1/20 0.39
▸ ERAP1 Q9NZ08 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Tryptophan SCHEMBL295706 0.93 MEN1 (0.46) KDM4EMEN1LMNAMPOMAPT
Dl-Tryptophan SCHEMBL27415496 0.82 KMT2A (0.63) KDM4EMEN1LMNAMPOMAPT
Tryptophan SCHEMBL5317118 0.82 KMT2A (0.63) KDM4EMEN1LMNAMPOMAPT
Dl-Tryptophan SCHEMBL28317266 0.81 KDM4E (0.53) KDM4EMEN1LMNAMPOMAPT
Dl-Tryptophan SCHEMBL27753251 0.81 KDM4E (0.60) KDM4EMEN1LMNAMPOMAPT
Tryptophan SCHEMBL3972882 0.81 KDM4E (0.60) KDM4EMEN1LMNAMPOMAPT
Tryptophan SCHEMBL3863016 0.81 KMT2A (0.65) KDM4EMEN1LMNAMPOMAPT
Tryptophan SCHEMBL4291975 0.80 MEN1 (0.57) KDM4EMEN1LMNAMPOMAPT
D-Tryptophan SCHEMBL2221757 0.80 KMT2A (0.57) KDM4EMEN1LMNAMPOMAPT
Phenylalanine SCHEMBL293835 0.80 MEN1 (0.44) KDM4EMEN1LMNAMPOMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2463378-B1 Alpha isomaltosylglucosaccharide synthase, process for producing the same and use thereof HAYASHIBARA CO (JP) 2015-12-23 — — EP disclosed
EP-1229112-B1 ALPHA-ISOMALTOSYLGLUCOSACCHARIDE SYNTHASE, PROCESS FOR PRODUCING THE SAME AND USE THEREOF HAYASHIBARA BIOCHEM LAB (JP) 2012-03-14 — — EP disclosed
EP-1445325-B1 PROCESSES FOR PRODUCING ISOMALTOSE AND ISOMALTITOL AND USE THEREOF HAYASHIBARA BIOCHEM LAB (JP) 2010-05-26 — — EP disclosed
EP-1360988-B1 METHOD FOR DEHYDRATING MOIST ARTICLE USING A CYCLOTETRASACCHARIDE HAYASHIBARA BIOCHEM LAB (JP) 2006-10-11 — — EP disclosed
EP-1445325-A1 PROCESSES FOR PRODUCING ISOMALTOSE AND ISOMALTITOL AND USE THEREOF Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo (JP) 2004-08-11 — — EP disclosed
EP-1360988-A1 DEHYDRATING AGENT AND METHOD FOR DEHYDRATING MOIST ARTICLE USING THE AGENT AND DEHYDRATED ARTICLE OBTAINED BY THE METHOD Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo (JP) 2003-11-12 — — EP disclosed
EP-1229112-A1 ALPHA-ISOMALTOSYLGLUCOSACCHARIDE SYNTHASE, PROCESS FOR PRODUCING THE SAME AND USE THEREOF Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo (JP) 2002-08-07 — — EP disclosed