Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 6/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.41 |
| ▸ | STS | P08842 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24326411 | 1.00 | TGFBR1 (0.42) | TGFBR1LMNAHTTKMT2ASIRT5 | |
| SCHEMBL29571019 | 0.97 | TGFBR1 (0.43) | TGFBR1LMNAHTTKMT2ASIRT5 | |
| SCHEMBL29570536 | 0.97 | TGFBR1 (0.43) | TGFBR1LMNAHTTKMT2ASIRT5 | |
| SCHEMBL24326268 | 0.97 | TGFBR1 (0.43) | TGFBR1LMNAHTTKMT2ASIRT5 | |
| SCHEMBL24326087 | 0.97 | TGFBR1 (0.43) | TGFBR1LMNAHTTKMT2ASIRT5 | |
| SCHEMBL24325432 | 0.90 | TGFBR1 (0.38) | TGFBR1LMNAHTTKMT2ASTS | |
| SCHEMBL29571083 | 0.90 | TGFBR1 (0.38) | TGFBR1LMNAHTTKMT2ASTS | |
| SCHEMBL27006667 | 0.90 | PKM (0.42) | LMNAHTTKMT2ASIRT5PKM | |
| SCHEMBL27010430 | 0.87 | LMNA (0.45) | LMNAHTTKMT2ASIRT5PKM | |
| SCHEMBL27010179 | 0.87 | LMNA (0.45) | LMNAHTTKMT2ASIRT5PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4225447-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | Vertex Pharmaceuticals Incorporated (US) | 2023-08-16 | — | — | EP | disclosed |
| WO-2022076625-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-04-14 | — | — | WO | disclosed |