Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | CSF1R | P07333 | 4/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.35 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.35 |
| ▸ | MGAM | O43451 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | SI | P14410 | 2/20 | 0.35 |
| ▸ | MGAM2 | Q2M2H8 | 2/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22717593 | 1.00 | MEN1 (0.35) | MEN1KMT2AL3MBTL1CSF1RNTRK1 | |
| SCHEMBL22717603 | 0.82 | MGAM (0.40) | MGAMGAASIMGAM2ALDH1A1 | |
| SCHEMBL22717753 | 0.77 | ALDH1A1 (0.41) | MEN1KMT2AMGAMGAASI | |
| SCHEMBL29574301 | 0.77 | ALDH1A1 (0.41) | MEN1KMT2AMGAMGAASI | |
| SCHEMBL6544885 | 0.74 | MEN1 (0.43) | MEN1KMT2AL3MBTL1CSF1RNTRK1 | |
| SCHEMBL22717613 | 0.73 | MBOAT4 (0.41) | — | |
| SCHEMBL22717738 | 0.73 | MGAM (0.37) | MEN1KMT2AL3MBTL1MGAMGAA | |
| SCHEMBL22717835 | 0.72 | PTGS1 (0.50) | MGAMGAASIMGAM2PTGS1 | |
| SCHEMBL22717405 | 0.72 | ALDH1A1 (0.54) | MEN1KMT2AMGAMGAASI | |
| SCHEMBL22717882 | 0.72 | ALDH1A1 (0.54) | MEN1KMT2AMGAMGAASI |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3976608-A1 | THIADIAZOLYL DERIVATIVES AS DNA POLYMERASE THETA INHIBITORS | Ideaya Biosciences, Inc. (US) | 2022-04-06 | — | — | EP | disclosed |