Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.50 |
| ▸ | GAA | P10253 | 6/20 | 0.50 |
| ▸ | HPGD | P15428 | 6/20 | 0.50 |
| ▸ | GLA | P06280 | 5/20 | 0.50 |
| ▸ | CASP1 | P29466 | 3/20 | 0.50 |
| ▸ | CASP7 | P55210 | 3/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.50 |
| ▸ | ATM | Q13315 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | CFTR | P13569 | 3/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24477918 | 1.00 | KDM4E (0.50) | KDM4EALDH1A1GAAHPGDGLA | |
| SCHEMBL29079159 | 0.95 | KDM4E (0.46) | KDM4EALDH1A1GAAHPGDGLA | |
| SCHEMBL24477888 | 0.85 | KDM4E (0.39) | KDM4EALDH1A1GAAHPGDGLA | |
| SCHEMBL24477889 | 0.85 | KDM4E (0.59) | KDM4EALDH1A1GAAHPGDGLA | |
| SCHEMBL30483543 | 0.85 | KDM4E (0.59) | KDM4EALDH1A1GAAHPGDGLA | |
| SCHEMBL26970374 | 0.84 | ASPH (0.32) | KDM4EALDH1A1GAAHPGDGLA | |
| SCHEMBL29079165 | 0.81 | KDM4E (0.54) | KDM4EALDH1A1GAAHPGDGLA | |
| SCHEMBL24477898 | 0.79 | GAA (0.61) | KDM4EALDH1A1GAAHPGDGLA | |
| SCHEMBL30483542 | 0.79 | GAA (0.61) | KDM4EALDH1A1GAAHPGDGLA | |
| SCHEMBL24477896 | 0.78 | KDM4E (0.51) | KDM4EALDH1A1GAAHPGDGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230416203-A1 | POTENT AND SELECTIVE INHIBITORS OF THE CALCIUM-ACTIVATED POTASSIUM CHANNEL, KCA3.1, FOR USE AS PLATFORM THERAPEUTICS | NANYANG TECHNOLOGICAL UNIVERSITY (SG) | 2023-12-28 | — | — | US | disclosed |
| EP-4251611-A1 | POTENT AND SELECTIVE INHIBITORS OF THE CALCIUM-ACTIVATED POTASSIUM CHANNEL, Kca3.1, FOR USE AS PLATFORM THERAPEUTICS | Nanyang Technological University (SG) | 2023-10-04 | — | — | EP | disclosed |
| WO-2022115043-A1 | POTENT AND SELECTIVE INHIBITORS OF THE CALCIUM-ACTIVATED POTASSIUM CHANNEL, KCa3.1, FOR USE AS PLATFORM THERAPEUTICS | NANYANG TECHNOLOGICAL UNIVERSITY (SG) | 2022-06-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230416203-A1 | POTENT AND SELECTIVE INHIBITORS OF THE CALCIUM-ACTIVATED POTASSIUM CHANNEL, KCA3.1, FOR USE AS PLATFORM THERAPEUTICS | KCNN3, KCNN1, KCNN2 | KDM4E 1441/4885ALDH1A1 3090/4885GAA 2829/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.