Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.64 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.64 |
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | HTT | P42858 | 2/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | PRSS1 | P07477 | 4/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2796146 | 1.00 | MAPT (0.66) | MAPTALDH1A1NPSR1POLBSMN1; SMN2 | |
| SCHEMBL112296 | 0.91 | ALDH1A1 (0.68) | MAPTALDH1A1NPSR1POLBSMN1; SMN2 | |
| SCHEMBL7973719 | 0.85 | ALDH1A1 (0.85) | MAPTALDH1A1NPSR1POLBSMN1; SMN2 | |
| SCHEMBL23092834 | 0.84 | MAPT (0.64) | MAPTALDH1A1NPSR1POLBSMN1; SMN2 | |
| SCHEMBL111519 | 0.84 | PRSS1 (0.55) | MAPTALDH1A1POLBSMN1; SMN2PKM | |
| SCHEMBL6233037 | 0.84 | ALDH1A1 (0.67) | MAPTALDH1A1POLBSMN1; SMN2LMNA | |
| SCHEMBL8645160 | 0.84 | ALDH1A1 (0.57) | MAPTALDH1A1POLBSMN1; SMN2PKM | |
| SCHEMBL7602927 | 0.83 | MAPT (0.64) | MAPTALDH1A1NPSR1POLBSMN1; SMN2 | |
| SCHEMBL4858189 | 0.82 | KAT2B (0.74) | MAPTALDH1A1POLBPKMTDP1 | |
| SCHEMBL8336041 | 0.82 | ALDH1A1 (0.56) | MAPTALDH1A1POLBSMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4232438-A1 | COMPOUNDS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | The Governors of the University of Alberta (CA) | 2023-08-30 | — | — | EP | disclosed |
| WO-2022082305-A1 | COMPOUNDS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | THE GOVERNORS OF THE UNIVERSITY OF ALBERTA (CA) | 2022-04-28 | — | — | WO | disclosed |