Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 1.00 |
| ▸ | GAA | P10253 | 1/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 1/20 | 1.00 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.66 |
| ▸ | NPC1 | O15118 | 1/20 | 0.66 |
| ▸ | LMNA | P02545 | 1/20 | 0.66 |
| ▸ | RAB9A | P51151 | 1/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.66 |
| ▸ | FLT3 | P36888 | 1/20 | 0.65 |
| ▸ | MAPT | P10636 | 1/20 | 0.62 |
| ▸ | DAO | P14920 | 1/20 | 0.62 |
| ▸ | HPGD | P15428 | 1/20 | 0.62 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.62 |
| ▸ | DRD2 | P14416 | 2/20 | 0.61 |
| ▸ | DRD3 | P35462 | 1/20 | 0.61 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.60 |
| ▸ | HTR2C | P28335 | 1/20 | 0.60 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.58 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL474835 | 1.00 | KDM4E (1.00) | KDM4EALDH1A1GAAMAPK1HSD17B10 | |
| SCHEMBL5279027 | 0.85 | KDM4E (0.74) | KDM4EALDH1A1GAAMAPK1HSD17B10 | |
| SCHEMBL721792 | 0.84 | KDM4E (0.72) | KDM4EALDH1A1GAAMAPK1HSD17B10 | |
| SCHEMBL31081137 | 0.84 | KDM4E (0.72) | KDM4EALDH1A1GAAMAPK1HSD17B10 | |
| SCHEMBL5164287 | 0.83 | KDM4E (0.71) | KDM4EALDH1A1GAAMAPK1HSD17B10 | |
| SCHEMBL1204954 | 0.82 | KDM4E (0.69) | KDM4EALDH1A1GAAMAPK1HSD17B10 | |
| SCHEMBL1204956 | 0.82 | KDM4E (0.69) | KDM4EALDH1A1GAAMAPK1HSD17B10 | |
| SCHEMBL23331084 | 0.82 | FLT3 (0.70) | KDM4EALDH1A1GAAMAPK1HSD17B10 | |
| SCHEMBL29354546 | 0.82 | KDM4E (0.70) | KDM4EALDH1A1GAAMAPK1HSD17B10 | |
| SCHEMBL1254745 | 0.82 | KDM4E (0.70) | KDM4EALDH1A1GAAMAPK1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114591295-B | Pyridine salt-containing N- (indolyl) -N' - (substituted) propyl hydrazide derivative, preparation method and application thereof | 贵州大学 | 2023-11-07 | — | — | CN | disclosed |
| US-20230183249-A1 | NEW TRIAZINOINDOLE COMPOUNDS | JANSSEN PHARMACEUTICA NV (BE) | 2023-06-15 | — | — | US | disclosed |
| EP-4143192-A1 | NEW TRIAZINOINDOLE COMPOUNDS | JANSSEN Pharmaceutica NV (BE) | 2023-03-08 | — | — | EP | disclosed |
| CN-115485280-A | Novel triazinoindole compounds | 詹森药业有限公司 | 2022-12-16 | — | — | CN | disclosed |
| CN-114591295-A | Pyridine salt-containing N- (indoleacyl) -N' - (substituted) propyl hydrazide derivative, and preparation method and application thereof | 贵州大学 | 2022-06-07 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230183249-A1 | NEW TRIAZINOINDOLE COMPOUNDS | NLRP3, NLRP1, PYCARD | KDM4E 4088/4885ALDH1A1 2700/4885GAA 3555/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.