Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Silver. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | PKLR | P30613 | 5/20 | 0.56 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.56 |
| ▸ | PGAM1 | P18669 | 2/20 | 0.56 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.50 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.47 |
| ▸ | STAT3 | P40763 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | CDC25B | P30305 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.46 |
| ▸ | EGFR | P00533 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | NSD2 | O96028 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31317955 | 0.96 | ALDH1A1 (0.59) | ALDH1A1SMN1; SMN2PKLRPTPN1PGAM1 | |
| SCHEMBL3511014 | 0.96 | ALDH1A1 (0.59) | ALDH1A1SMN1; SMN2PKLRPTPN1PGAM1 | |
| SCHEMBL5068680 | 0.96 | ALDH1A1 (0.59) | ALDH1A1SMN1; SMN2PKLRPTPN1PGAM1 | |
| SCHEMBL1412691 | 0.96 | ALDH1A1 (0.59) | ALDH1A1SMN1; SMN2PKLRPTPN1PGAM1 | |
| SCHEMBL29622863 | 0.96 | ALDH1A1 (0.59) | ALDH1A1SMN1; SMN2PKLRPTPN1PGAM1 | |
| SCHEMBL30469515 | 0.96 | ALDH1A1 (0.59) | ALDH1A1SMN1; SMN2PKLRPTPN1PGAM1 | |
| Potassium Ion SCHEMBL2787084 | 0.96 | ALDH1A1 (0.59) | ALDH1A1SMN1; SMN2PKLRPTPN1PGAM1 | |
| Water SCHEMBL28390010 | 0.94 | ALDH1A1 (0.57) | ALDH1A1SMN1; SMN2PKLRPTPN1PGAM1 | |
| SCHEMBL2786330 | 0.90 | STAT3 (0.52) | ALDH1A1SMN1; SMN2PKLRPTPN1PGAM1 | |
| Potassium Ion SCHEMBL2788338 | 0.90 | STAT3 (0.52) | ALDH1A1SMN1; SMN2PKLRPTPN1PGAM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7759045-B2 | Chemically amplified positive resist composition | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2010-07-20 | — | — | US | disclosed |
| US-20090004601-A1 | Chemically amplified positive resist composition | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2009-01-01 | — | — | US | disclosed |