Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.48 |
| ▸ | RAB9A | P51151 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | DPP4 | P27487 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24423905 | 1.00 | NPC1 (0.48) | NPC1RAB9AKMT2AMEN1DPP4 | |
| SCHEMBL24423445 | 0.88 | GAA (0.40) | RAB9AKMT2AGAA | |
| SCHEMBL29584681 | 0.88 | GAA (0.40) | RAB9AKMT2AGAA | |
| SCHEMBL29585699 | 0.87 | ALDH1A1 (0.41) | NPC1RAB9AKMT2AALDH1A1KDM4E | |
| SCHEMBL24424363 | 0.83 | FFAR4 (0.37) | — | |
| SCHEMBL29585218 | 0.83 | NPC1 (0.40) | NPC1RAB9AKMT2AMEN1ALDH1A1 | |
| SCHEMBL24424619 | 0.82 | KDM5A (0.40) | KMT2AMEN1ALDH1A1 | |
| SCHEMBL29583319 | 0.82 | KDM5A (0.40) | KMT2AMEN1ALDH1A1 | |
| SCHEMBL24423815 | 0.81 | MEN1 (0.46) | KMT2AMEN1ALDH1A1 | |
| SCHEMBL24423814 | 0.81 | MEN1 (0.46) | KMT2AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4240736-A1 | PPAR GAMMA MODULATORS AND METHODS OF USE | Eisai R&D Management Co., Ltd. (JP) | 2023-09-13 | — | — | EP | disclosed |
| WO-2022099144-A1 | ΡΡΑRγ MODULATORS AND METHODS OF USE | Eisai R&D Mangement Co., Ltd. (JP) | 2022-05-12 | — | — | WO | disclosed |