Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 13/20 | 0.40 |
| ▸ | RAB9A | P51151 | 13/20 | 0.40 |
| ▸ | HPGD | P15428 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALPL | P05186 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | TACR3 | P29371 | 1/20 | 0.37 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24424425 | 0.87 | NPC1 (0.42) | NPC1RAB9AHPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL24423445 | 0.87 | GAA (0.40) | RAB9AKMT2ATBK1 | |
| SCHEMBL29584681 | 0.87 | GAA (0.40) | RAB9AKMT2ATBK1 | |
| SCHEMBL24424363 | 0.86 | FFAR4 (0.37) | TACR3TBK1 | |
| SCHEMBL29585699 | 0.86 | ALDH1A1 (0.41) | NPC1RAB9AHPGDALDH1A1KMT2A | |
| SCHEMBL29585365 | 0.85 | RAB9A (0.40) | NPC1RAB9AHPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL24423119 | 0.84 | FFAR4 (0.37) | TBK1 | |
| SCHEMBL29585889 | 0.84 | FFAR4 (0.37) | TBK1 | |
| SCHEMBL29585378 | 0.83 | NPC1 (0.48) | NPC1RAB9AHPGDALDH1A1POLB | |
| SCHEMBL24423081 | 0.82 | MGLL (0.39) | TBK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4240736-A1 | PPAR GAMMA MODULATORS AND METHODS OF USE | Eisai R&D Management Co., Ltd. (JP) | 2023-09-13 | — | — | EP | disclosed |
| WO-2022099144-A1 | ΡΡΑRγ MODULATORS AND METHODS OF USE | Eisai R&D Mangement Co., Ltd. (JP) | 2022-05-12 | — | — | WO | disclosed |