Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGLL | Q99685 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 5/20 | 0.41 |
| ▸ | HSPB1 | P04792 | 2/20 | 0.41 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.39 |
| ▸ | PTPN12 | Q05209 | 1/20 | 0.39 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | BCL9 | O00512 | 1/20 | 0.39 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.39 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29586022 | 0.86 | ALDH1A1 (0.47) | MGLLGAAMAPTNPSR1MAPK1 | |
| SCHEMBL29586959 | 0.86 | ALDH1A1 (0.47) | MGLLGAAMAPTNPSR1MAPK1 | |
| SCHEMBL29586644 | 0.83 | GAA (0.48) | MGLLGAAMAPTNPSR1MAPK1 | |
| SCHEMBL29587337 | 0.80 | MGLL (0.43) | MGLLGAAMAPTNPSR1ALDH1A1 | |
| SCHEMBL15664050 | 0.80 | ALDH1A1 (0.51) | MGLLGAAALDH1A1BCL9CTNNB1 | |
| SCHEMBL30779373 | 0.79 | GAA (0.48) | MGLLGAAMAPTMAPK1ALDH1A1 | |
| SCHEMBL29586103 | 0.78 | PTPN7 (0.46) | MGLLGAAMAPTNPSR1MAPK1 | |
| SCHEMBL29586105 | 0.77 | GAA (0.47) | MGLLGAAMAPTALDH1A1PTPN7 | |
| SCHEMBL29587529 | 0.76 | GAA (0.47) | MGLLGAAMAPTMAPK1ALDH1A1 | |
| SCHEMBL15663909 | 0.75 | ALDH1A1 (0.51) | MGLLGAAMAPTMAPK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12428413-B2 | Rho kinase inhibitors and compositions and methods of use thereof | CHDI FOUNDATION, INC. (US) | 2025-09-30 | — | — | US | disclosed |
| EP-3990442-B1 | RHO KINASE INHIBITORS AND COMPOSITIONS AND METHODS OF USE THEREOF | CHDI FOUNDATION INC (US) | 2024-02-28 | — | — | EP | disclosed |
| US-20220388998-A1 | RHO KINASE INHIBITORS AND COMPOSITIONS AND METHODS OF USE THEREOF | CHDI FOUNDATION, INC. | 2022-12-08 | — | — | US | disclosed |
| EP-3990442-A1 | RHO KINASE INHIBITORS AND COMPOSITIONS AND METHODS OF USE THEREOF | CHDI Foundation, Inc. (US) | 2022-05-04 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12428413-B2 | Rho kinase inhibitors and compositions and methods of use thereof | ROCK1, ROCK2, RHOA | MGLL 3361/4885GAA 828/4885HSPB1 826/4885 |
| US-20220388998-A1 | RHO KINASE INHIBITORS AND COMPOSITIONS AND METHODS OF USE THEREOF | ROCK1, ROCK2, RHOA | MGLL 3361/4885GAA 828/4885HSPB1 826/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.