Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 3/20 | 0.46 |
| ▸ | PPARG | P37231 | 4/20 | 0.45 |
| ▸ | PPARA | Q07869 | 4/20 | 0.45 |
| ▸ | MMP1 | P03956 | 4/20 | 0.45 |
| ▸ | PPARD | Q03181 | 3/20 | 0.45 |
| ▸ | MMP13 | P45452 | 2/20 | 0.45 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.43 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.43 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.42 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 2/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | HTR6 | P50406 | 1/20 | 0.42 |
| ▸ | MGLL | Q99685 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | SLC26A4 | O43511 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29586901 | 0.84 | CYP4F2 (0.49) | PPARGPPARAPPARDNR4A2NPC1 | |
| SCHEMBL29587246 | 0.83 | MAOB (0.48) | ADAM17PPARGPPARAMMP1PPARD | |
| SCHEMBL29586773 | 0.83 | PPARG (0.41) | PPARGPPARAPPARDNR4A2NPC1 | |
| SCHEMBL29588229 | 0.79 | PPARG (0.51) | ADAM17PPARGPPARAPPARDCYP4F2 | |
| SCHEMBL29588068 | 0.79 | MAOB (0.48) | ADAM17PPARGPPARAPPARDNPC1 | |
| SCHEMBL29586744 | 0.79 | NPC1 (0.49) | ADAM17PPARGPPARAMMP1MMP13 | |
| SCHEMBL9215960 | 0.78 | NR4A2 (0.44) | ADAM17MMP1MMP13NR4A2NPC1 | |
| SCHEMBL29586818 | 0.78 | ADAM17 (0.52) | ADAM17PPARGPPARAMMP1NPC1 | |
| SCHEMBL29586764 | 0.77 | PSEN1 (0.50) | NPC1RAB9AMEN1KMT2A | |
| SCHEMBL27091892 | 0.77 | MAOB (0.47) | ADAM17PPARGPPARAMMP1PPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022120048-A1 | HDAC INHIBITORS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2022-06-09 | — | — | WO | disclosed |