Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | POLQ | O75417 | 1/20 | 0.34 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.34 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | CNR1 | P21554 | 1/20 | 0.30 |
| ▸ | QDPR | P09417 | 1/20 | 0.30 |
| ▸ | WDR5 | P61964 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24313735 | 1.00 | HTR2A (0.35) | HTR2AHTR2CHTR2BPOLQESR2 | |
| SCHEMBL24313611 | 0.78 | ESR2 (0.36) | ESR2CNR1QDPR | |
| SCHEMBL24313743 | 0.77 | HTR2A (0.42) | HTR2AHTR2CHTR2BPOLQALDH1A1 | |
| SCHEMBL12174452 | 0.77 | HDAC4 (0.42) | ESR2QDPR | |
| SCHEMBL679035 | 0.74 | CES2 (0.39) | KDM4EALDH1A1POLB | |
| SCHEMBL684806 | 0.73 | ERN1 (0.39) | ALDH1A1POLB | |
| SCHEMBL24314202 | 0.71 | ESR2 (0.34) | ESR2CNR1QDPR | |
| SCHEMBL29587536 | 0.71 | ESR2 (0.34) | ESR2CNR1QDPR | |
| SCHEMBL24313734 | 0.71 | ERN1 (0.36) | ESR2KDM4E | |
| SCHEMBL29587472 | 0.71 | ERN1 (0.36) | ESR2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4229045-A1 | SUBSTITUTED ACYL SULFONAMIDES FOR TREATING CANCER | The Broad Institute Inc. (US) | 2023-08-23 | — | — | EP | disclosed |
| WO-2022081842-A1 | SUBSTITUTED ACYL SULFONAMIDES FOR TREATING CANCER | THE BROAD INSTITUTE, INC. (US) | 2022-04-21 | — | — | WO | disclosed |