SCHEMBL29590048

SCHEMBL29590048

c1cncc(-c2cccs2)c1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2A6 P11509 10/20 1.00
CYP3A4 P08684 5/20 1.00
CYP2C9 P11712 4/20 1.00
CYP2B6 P20813 4/20 1.00
CYP2E1 P05181 3/20 1.00
KDM4E B2RXH2 5/20 0.67
ALDH1A1 P00352 5/20 0.67
HSD17B10 Q99714 4/20 0.67
HPGD P15428 4/20 0.67
RAB9A P51151 2/20 0.67
MAPK1 P28482 1/20 0.65
CYP1A2 P05177 1/20 0.58
FYN P06241 1/20 0.55
DYRK1A Q13627 1/20 0.55
DYRK1B Q9Y463 1/20 0.55
CYP2C19 P33261 3/20 0.52
CYP2D6 P10635 2/20 0.52
CYP17A1 P05093 1/20 0.52
CYP11B1 P15538 1/20 0.52
CYP11B2 P19099 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL158705 1.00 CYP2A6 (1.00) CYP2A6CYP3A4CYP2C9CYP2B6CYP2E1
SCHEMBL19219088 0.92 CYP2A6 (0.85) CYP2A6CYP3A4CYP2C9CYP2B6CYP2E1
SCHEMBL9192615 0.87 CYP2A6 (0.76) CYP2A6CYP3A4CYP2C9CYP2B6CYP2E1
SCHEMBL28373020 0.86 CYP2A6 (0.74) CYP2A6CYP3A4CYP2C9CYP2B6CYP2E1
Pyridine SCHEMBL30984530 0.83 CYP3A4 (0.70) CYP2A6CYP3A4CYP2C9CYP2B6CYP2E1
SCHEMBL28511535 0.82 CYP2A6 (0.69) CYP2A6CYP3A4CYP2C9CYP2B6CYP2E1
SCHEMBL23004809 0.82 CYP2E1 (0.69) CYP2A6CYP3A4CYP2C9CYP2B6CYP2E1
SCHEMBL9058679 0.81 RAB9A (1.00) CYP2A6CYP3A4CYP2C9CYP2B6CYP2E1
SCHEMBL1357023 0.80 CYP2A6 (0.67) CYP2A6CYP3A4CYP2C9CYP2B6CYP2E1
SCHEMBL18789395 0.80 CYP3A4 (0.67) CYP2A6CYP3A4CYP2C9CYP2B6CYP2E1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110003271-B Process for producing aromatic compound 住友化学株式会社 2022-05-03 CN disclosed